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Fda Approves Drug That Keeps Prostate Cancer At Bay For Long Time

Prostate cancer is one of the cancers that are common across the world. As per the statistics, it is known to be the second most common cancer in the US and UK and the sixth common cause of cancer deaths in the world. As far as India is concerned, the rates earlier were quite lower compared to other countries. But, the recent data shows a rise in cancer in India and mostly in urban areas, particularly since the time.

prostate cancer

Now, males hormones are such that they only aid in worsening the symptoms and aiding its spread. Nubeqa or darolutamide is the new drug that is effective in controlling cancer spread. It has the ability to increase the life expectancy rates by more than double.

As per the trial investigator and medical direction Neal Shore of Carolina Urologic Research Centre Prostate cancer particularly that’s spread across the other body parts is highly sensitive to the spread fast under the influence of male hormones like testosterone and testosterone metabolites.

Shore added the initial trials of the drug were a success as the tolerance was quite good events unique to ARIs that were observed in the earlier trials are not observed with darolutamide. Only that certain side effects like Nubeqa, rash and fatigue

He also added that the FDA approved the med only after it cleared the Phase III ARAMIS trial with positive results showing a rise in metastasis-free survival (MFS). Published in the New England Journal of Medicine earlier this year, had carried out the trial that involved 1509 participants who were provided with 600 mg of the oral drug two times a day or a placebo alongside ADT. The randomized trial was multicenter, double-blinded, and placebo-controlled on men with nmCRPC and under the treatment of androgen deprivation therapy (ADT) with higher chances of turning out to be metastatic.

Robert Lacaze, executive member of the pharmaceuticals division as well as strategic business head at Bayer stated that Nubeqa’s approval had opened gates to a new therapy that aids in extending MFS besides allowing physicians more flexibility in treating men having nmCRPC.

As per Matthew Smith, MD, Ph.D., director at the Massachusetts General Hospital Cancer Centre in Boston for Genitourinary malignancies program, The approval of Nubeqa has opened the gates for a new option in prostate cancer treatment. He added that the objective of the treatment was to curb the spread of cancer besides controlling therapy side effects as Patients usually do not exhibit any typical symptoms of MFS.

Biopsy – All You Need To Know About Biopsy

For a variety of cancers the only way to provide a definite diagnosis about a condition is to carry out biopsy. The procedure involves the removal of a sample of cells or a tissue from the body for a closer examination.

Biopsy - Types of Biopsy

Types of Biopsy

Needle Biopsy – This type of biopsy is used mostly for diagnosis of cancers that can be felt through the skin. These include enlarged lymph nodes as well as breast nodes

  • Fine needle aspiration A needle and a syringe is used to get a sample from either breast lump or thyroid.

  • Vacuum assisted biopsy – There’s a suction device is used to extract more amount of fluid at a time so that the needle does not have to be inserted many times.

  • Image guided biopsy - Image guided biopsy uses a combination of imaging procedures like computerized tomography (CT), X-ray, sonography or MRI.

  • Core needle biopsy – It uses a needle that is larger with a cutting tip to draw the sample column of tissue.

Endoscopic Biopsy- An endoscope is used for taking tissues from the stomach during endoscopy. An endoscope is a tube with a camera at its end.

Incisional Biopsy – It involves taking a small part of skin

Excisional Biopsy – It involves taking a big part of the tissue/ tumor and requires a

Skin Biopsy – The procedure is carried out in order to check for lesions, rashes, growth, moles and lesions. The doctor takes samples of your skin surface with the help of a razor.

Punch Biopsy – A small instrument is used to punch a hole in the skin in order to get a sample.

Bone Marrow Biopsy – This biopsy involves taking samples of the bone marrow to check for cancerous or non-cancerous cells causing blood problems. A sample of the bone marrow is taken for diagnosis around cancers like lymphoma, leukemia and more.

Yes, biopsy does sound freaky but with the advanced procedures in place, its mostly a low risk as well as pain free procedure. So, if you are to undergo a biopsy procedure soon, do not panic. Stay calm, there’s nothing to worry about it.

*Sourced from the Internet

Just know about VIMS &RC

Effects Of Cancer On Mental Health

Even today after so much advancement in the field of healthcare and medicine and so much rewarding research around cancer, it still remains a dreaded disease for people. Yes, innovation and research in the cancer field have brought about a lot of hope in terms of increasing longevity and improvement in quality of life, even today when we hear of been diagnosed with cancer, we do get goosebumps or a shocker. These days’ people have become quite vocal about disclosing the diagnosis to people and sharing their experiences, particularly celebrities are quite vocal about it. Even though, different people experience differently depending upon their individual mental health.

Most of us feel that having cancer means a physical condition that is life-threatening, causes fatigue, hair loss, and nausea. But, beyond physical issues, comes the mental health issue which we are not able to see. Some might tell about it while some may not but the fact of the matter remains that hearing the news does not get easier for anyone. There comes some point in life where most cancer patients slip into depression. Here are the most common feelings that storm through the minds of cancer survivors –

cancer Hospital in Bangalore

DEPRESSION – As per the National Cancer Institute, depression is known to affect around 15 to 25 percent of the cancer population. The condition is a result of diagnosis itself primarily. Other reasons for depression include cancer side effects, anxiety around the future with cancer, change in the image of self, to name a few. Depression is not the same as feeling sad, it comes with symptoms like fatigue, emptiness, mood swings, worthlessness to name a few.

GRIEF – Grief is not limited to the cancer patient but to his family and relatives as well for the period through the cancer battle. There is this term called anticipatory grief, apparently a mix of emotions that come when we live with a personal loss experience that results in grieving. This same grief is experienced by cancer patients and their relatives. Although it is normal to experience grief in such times, grieving alone isn’t advisable.

ANXIETY – Anxiety is one of the most common problems that cancer patients face around their future prognosis, future reports, treatment-related issues to name a few. The cancer community has also coined a special work for anxiety around future scans, calling it scanxiety.

All these mental health issues do need to be looked into and consulting a mental health specialist or therapist surely does help. Well, it important to understand that if mental health is better, the healing is faster and even the quality of life.

Risk of Breast Cancer in Trans Women Post Hormone Therapy Escalates To Over 45 Times

A study has found that trans-women undergoing gender change procedures increase their risk of getting breast cancer by over 46% as compared to men. The study was carried out on over 2000 trans-women and it was found that after undergoing the sex-change procedures 1 in 200 came under the risk scanner of breast cancer as compared to less than 8000 in men.

Cancer hospital in Bangalore

The studies that were carried out earlier have shown that hormone replacement therapy (HRT) does increase the risk of breast cancer, particularly in women post-menopause. Suggestively, it would increase the risk in trans-women undergoing hormone treatment.

As a study involving 2260 women, 15 cases of invasive breast cancer came to light of that of women of over 50 years of age post 18 years on an average of hormone therapy. Dr. Martin Den Heijer from Amsterdam University Medical Centre says that the issues and side effects of hormone therapy are knowns are discussed also with the people who undergo treatment.

Though the risk for naturally born women is one-third less, the experts from the Netherlands said that not only the patients but even the doctors needed to be aware of the fact that injections of female hormones do have an increased threat.

In Britain, there has been a drastic rise in the number of operations and it’s around 250 per year presently as compared to 54 around 2000. The researchers were unclear though if some of the cases were genetic or due to lifestyle because one of their transgender woman studies did carry the BRCA gene mutation that leads to breast cancer. Besides, it also showed that transgender men were at a considerably lower risk as compared to the female population. The study that determined the same involved 1229 trans men of which four had invasive breast cancer have diagnosed at 47 years post 15 years of hormone treatment.

A Startup Uses AI For Early Detection of Breast Cancer – Bengalure

A Startup in Bengaluru that uses artificial intelligence to detect breast cancer at an early stage has raised 6 million as funding. We all are aware that Breast Cancer is one of the most common cancers in India and thus does have a potential for huge business as well has social impact. The funds are needed for the organization to get the regulatory approvals, hire talent and expand in India primarily. The technology used by the startup is the key to early detection of the disease because there already is a shortage of skilled professionals and the breast ratio is too high too. The Japan based startup that has funded this Indian startup is also going to help the company expand internationally in Japan.

AI - Breast Cancer

Though the startup was launched in 2016, with an objective of using AI to replace the present methods of mammography, which is an expensive equipped and a must for radiographers. The solution they offer is known as thermal-tix which is not only non-touch, but radiation free and non-painful imaging method.

As per the representative of the company, Nirmai as of now is the only company in the world that uses AI based thermal image processing as well as machine learning algorithms for reliable and trust worthy breast cancer screening. It is in the process of deploying its solution across 21 hospitals in 9 different cities. The representative also mentioned that the solution is an innovation and hence the implementation of it does require time. The organization is looking to touch-base rural areas besides metros, I and II tier cities.

One of the recognitions that already is in the kitty of this Bengaluru based startup is that it is the only Indian startup to be showcased under the CB (global business data intelligence platform) Insights 3rd annual list of 100 most promising startups across the world.

VIMS is one of the best cancer hospital in india, with 300 beds exclusively for cancer patients.Oncology department in the hospital has got qialified and well experienced doctors

*Source From the Internet

All You Need to Know About the Cancer Hrithik Roshan is Suffering From

Recently, the celebrated Film Director Rakesh Roshan was diagnosed with early-stage throat cancer. The news was shared on social media by his son, film star Hrithik Roshan. For the past two years, many movie celebrities shared their experiences around having cancer and how life changed for them after getting to know about the cancerous conditions they had. This included notable actors like Irfan Khan, Nafisa Ali, Sonali Bendre, to name a few. While for Rakesh Roshan it is good news in a way because his cancer got detected early on, helping him and the doctors to provide treatment and help get rid of eating at the initial stage.

rakesh-cancer-hrithik

Rakesh Roshan is suffering from early-stage squamous cell carcinoma of the throat and had to undergo surgery as well. Throat cancer is not new in India and occurs due to the growth of abnormal cells around the throat lining in an uncontrolled manner. The cancer is quite common in Indians and occurs mostly in age groups of 50 and above. It is a consideration under the category of cancers for the head and neck. In oncology throat and neck, cancers come under one category because they have similarities in their type, pathological features, predisposing factors, cancer types, and more.

Throat cancer includes cancers around the vocal cord, tonsil, voice box, and oropharynx. There are two categories of throat cancers namely pharyngeal and laryngeal cancer. The two primary types include the Squamous cell carcinoma and Adenocarcinoma.

Squamous Cell Carcinoma – Known to be one of the most common forms of throat cancer, this affects the throat’s flat cell lining.

Adenocarcinoma – This cancer is not as common as the first one and affects the glandular cells.

Symptoms
Early detection of cancer is not easy but if it is, consider it as a boon. It helps to give appropriate treatment and curb it and eliminate it as well. Symptoms include weight loss, trouble with swallowing, change in voice, swollen lymph nodes, ear pain, wheezing, and persistent cough to name a few.

Risk Factors
Men are known to be at a higher risk than women when it comes to getting throat cancer. Even lifestyle that includes addictions like excess alcohol, smoking, genetics, poor dental hygiene, and nutrition as well as asbestos exposure increases the chances of getting throat cancer.

Treatment
The treatment depends on the diagnosis and could include surgery and or radiation therapy and chemotherapy.

  • Surgery – Depending on the size of the tumor, the surgery could be an endoscopic one or it could be cordectomy wherein a part or complete vocal chord is removed. When a part of your chord is removed it is known as a laryngectomy, while when a part of your throat is removed it is known as Pharyngectomy. If the cancer is spread across the neck then it is known as dissection.
  • Radiation Therapy: There are two types of radiation therapies namely
  1. Intensity-modulated radiotherapy / 3D conformal radiation therapy – These treatments customize the radiations as per the tumor shape and is a common technique used in cancers like hypopharyngeal and laryngeal cancer.
  2. Brachytherapy – This is not a common type of radiation therapy and includes placing radioactive seeds within the tumor.
  • Chemotherapy – Chemotherapy is one of the common treatments given to cancer patients either with or without radiation therapy. This is given when the tumor has spread through the lymph nodes to other parts or tissues.

Treatment of this cancer can cause side effects like difficulty with breathing, swallowing food, disfigurement of face or neck, difficulty with speaking, and hardening around the neck to name a few. With the help of occupational therapists, you can learn to deal with such issues.

Early detection of throat cancer means a high survival rate. While if detected later, the speed could be slowed down thus prolonging life span through treatment.

Cancer Vaccine that can Cure 97% of Tumor from Mice Approved for Human Trial

Yes, you read that right. As per researchers of Stanford University, a vaccine they tested on mice has worked well in curing around 97% of the tumors in mice and is ready for human trial. According to SFGate. the human trial is scheduled to be conducted on 35 people suffering from lymphoma before the year ends.

The study was earlier tested on mice with cancers ranging from colon, breast and lymphoma. The results were welcoming, because this treatment cured around 87 mice out of the 90. The best part is that tumors in some mice had spread through other parts of the body too and even then they could be cured.

Cancer Vaccine That can Cure 97% of Tumor from Mice Approved for Human trial

As per the regional director of breast surgery at North-well Health Cancer Institute in Westchester, New York, even if the news was exciting enough, the results on animals might not be the same as that on humans. So, there is still a long way to go before the treatment works for particularly cancers other than lymphoma, viz. breast and colon.

Though it is called a vaccine, technically it ain’t. It is more of an immunotherapy. It is still given the name of a vaccine for a reason that is does contain a vaccine like injection. Also, as per the American society of clinical oncology, cancer vaccines can be used for referring treatment of cancer and preventing it from coming back. This vaccine involves the injection of the vaccine into the existing tumor. It does the role of reactivating the T cells. These T cells are responsible for infiltrating and attacking the cancer cells. But, as the tumor increases, the cancer tells suppress these T cells.
Immunotherapy is not something new though. It has been in practice for quite some time. A treatment called CAR t-cell therapy has been already approved some time back for leukemia as well as lymphoma. This therapy is about removing certain immune cells from the body and genetically engineer these cells so that they become capable of fighting cancer.

But, the advantage of this therapy over CAR T-cell therapy is that nothing from the body is to be removed or customized. Here it’s just targeted therapy where the doctors will be concentrating and attacking specific targets.

Though this study is one step forward in the direction to treat cancer but still it’s a long way to go.

Vydehi Institute of Oncology & Research Centre is one of the first centers in India to commission IGRT (Image guided radiation therapy) with respiratory gating apart from having other radiation equipment like High Dose Rate Brachytherapy (HDR).

*Source from the Internet

One Blood Test to Diagnose 8 Different Cancers

A recent study has revealed the ability of one blood test to detect as many as eight types of cancers with perfection. The study was carried out by a team of researchers at the John Hopkins University of Medicine, Baltimore, and even published in the Science Journal. The study was carried out over 1000 people with the disease and showed high specificity and sensitivity as well.

Today, even with many innovations and advances in science, Cancer is still not having a cure. While research is on, the estimated death toll by 2030 across the world due to cancer can go up to a staggering 8-13 million range.

One Blood Test to Diagnose 8 Different Cancers

Because, the cure is still to be found, the effectiveness of the treatment is limited to restricting the spread of the cancer cells and increasing life span. An early diagnosis is always beneficial in cancer but sadly, by the time you become aware of cancer in your body, it is too late and its spreads to other parts. The reason is the lack of advanced tools for diagnosis. But, here’s some good news from the research team at John Hopkins University could crack the code to a simple way to detect cancer that too in the early stages.

The idea is to detect small fragments of mutated DNA as well as proteins that the cancerous tumors release in the bloodstream when they are formed, thus helping to detect cancer through a blood test. The researchers revealed that the new blood test has the ability to identify 16 gene mutations as well as 8 proteins linked to eight different cancer types.

The cancers include colorectal cancer, lung cancer, breast cancer, and five others that even today do not have routine screening tests for people with average risk namely pancreatic cancer, liver cancer, esophageal cancer, stomach cancer, and ovarian cancer.

As per Cristian Tomasetti, associate professor of oncology and biostatistics of John Hopkins University, the uniqueness of this classification method in observing different levels of Proteins together with DNA mutations in order to reach a final decision.

The Cancer SEEK test was performed on 1005 individuals in total and successfully identified 70% of the cancers with high sensitivity ranging from 33% in breast cancer cases and up to 98% in ovarian cancer cases. In the five cancers which do not have routine screenings, the test performed even better showing a sensitivity of 69% to 98%.

As far as specificity is concerned the range was 99% and out of the 812 people tested, it only showed seven false results. What’s more, the test was even able to detect the location of the tumor in over 80% of the patients.

As per the researchers, it will take further study to determine its efficacy as a routine screening test for cancer detection but the results are encouraging and definitely paves the way towards improving the quality of life of cancer patients through early detection.

How Trojan Horse Treatment is the new Hope in Fighting Brain Tumor?

One of the common, as well as highly aggressive tumors of the brain, is the Glioblastoma multiforme. Once, the diagnosis is done, many patients die within a few months period. The survival rate for this tumor is as low as 6 patients out of 100 being able to live for 5 years period or more. This is one cancer that has shown a lot of resistance against treatments. One of the main reason behind the same is because this tumor invades the healthy brain tissues surrounding it, thus making it impossible to remove it surgically.

The research was carried out by engineering nanostructures containing both conventional chemotherapy drugs namely cisplatin and gold. These nanospheres were released to the tumor cells were taken from patients suffering from glioblastoma, taken to the laboratory, and grown followed by exposure to radiotherapy. The results were quite amazing and after 20 days, the tumor cells were totally destroyed without any proof of revival. The treatment was more effective than conventional chemotherapy because it enhanced the impact of it by helping gold to release electrons that caused damage to the DNA of the cancer cells and the overall structure as well.

Brain Tumor

This is a stepping stone in the treatment of aggressive brain tumors and as per the experts in Nanotechnology but work is still in progress before this treatment can be used for patients suffering from glioblastoma. The best part of the experiment was that it was carried out on tumors of glioblastoma patients, where the experts tested this approach drug-resistant tumors that were evolving.

The study was carried out by Dr. Colin Watts, a clinical scientist as well as an honorary consultant Neurosurgeon at the Clinical Neurosciences, and Mark Wellan, Professor of Nanotechnology and Fellow at St John’s College, University of Cambridge. This work of theirs is published in the Royal Society of Chemistry Journal call Nanoscale.

As per Professor Welland, their combined therapy seems to be highly effective particularly with live cell culture. This is definitely not a cure for cancer but throws light on how nanotechnology can play a significant role in fighting this aggressive cancer. Researchers also believe that this treatment procedure could be used for treating a variety of different and challenging cancer types.

The professor also harped upon the big advantage the nanoscientists had by working with clinicians because they could ensure that this science does have a clinical relevance through their involvement. This further ensures that the idea can be realized and implemented beyond the labs due to its clinical impact.

A Technique To Destroy Cancer Cells Within Three Days

A new study has further raised the hope for treating cancer faster due to the easy technique which alters the structure of chromatin in cancer cells thus destroying them faster and in an easier way.

Now chromatin is formed from DNA that are wrapped around proteins and called Histones. Chromatin is responsible for regulating the genes that are switched on and off besides packaging the genetic code into the cell nucleus properly. In technical language you may put chromatin as the software if the genetics is termed as hardware.

A Technique To Destroy Cancer Cells Within Three Days

Though chromatin works for cancer cells in a way because it aids in their evolution and helps them adapt to cancer therapies, ultimately helping them survive and grow.
Cancer being a complex condition, individual behavior of genes does not make a difference but it all actually depends on the complex interplay of the thousands of genes. Hence, the researchers focused on chromatin for fighting cancer.

They developed the technique called Partial Wave Spectroscopic (PWS) microscopy, which allows real time monitoring of chromatin in living cells. They used this technique in cultured cancer cell and found that chromatin helps cancer cells evade treatment due to the specific packaging density linked with gene expression.

The more disordered and heterogenous the chromatin packaging density, the more ordered and conservative it is, the more are the chances of cancer cell death while responding to chemotherapy. Thus as per the discovery made, the researchers came to hypothesis that changing the chromatin structure and making it orderly can actually help in increasing cancer cells treatment vulnerability. Further study made them understand the fact that it was possible to modify the chromatin structure in the nucleus of the cancer cells by electrolytes.

The researchers tried combining two drugs one Celecoxib used for pain relief and Digoxin used for treating fibrillation as well as heart failure. Referring this combination as chromatin protection therapeutics (CPTs), they tested it on cancer cells in the lab with chemotherapy and the results according to the researchers were remarkable.

The researchers have also successfully replicated the finding in seven different cancer kinds which is a ray of hope in the cancer treatment.

Vydehi is one of the best cancer hospital in banglaore, recently vims started VOICE – Vydehi Oncology Institute and Center of Excellence

*Source form internet