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Fda Approves Drug That Keeps Prostate Cancer At Bay For Long Time

Prostate cancer is one of the cancers that are common across the world. As per the statistics, it is known to be the second most common cancer in the US and UK and the sixth common cause of cancer deaths in the world. As far as India is concerned, the rates earlier were quite lower compared to other countries. But, the recent data shows a rise in cancer in India and mostly in urban areas, particularly since the time.

prostate cancer

Now, males hormones are such that they only aid in worsening the symptoms and aiding its spread. Nubeqa or darolutamide is the new drug that is effective in controlling cancer spread. It has the ability to increase the life expectancy rates by more than double.

As per the trial investigator and medical direction Neal Shore of Carolina Urologic Research Centre Prostate cancer particularly that’s spread across the other body parts is highly sensitive to the spread fast under the influence of male hormones like testosterone and testosterone metabolites.

Shore added the initial trials of the drug were a success as the tolerance was quite good events unique to ARIs that were observed in the earlier trials are not observed with darolutamide. Only that certain side effects like Nubeqa, rash and fatigue

He also added that the FDA approved the med only after it cleared the Phase III ARAMIS trial with positive results showing a rise in metastasis-free survival (MFS). Published in the New England Journal of Medicine earlier this year, had carried out the trial that involved 1509 participants who were provided with 600 mg of the oral drug two times a day or a placebo alongside ADT. The randomized trial was multicenter, double-blinded, and placebo-controlled on men with nmCRPC and under the treatment of androgen deprivation therapy (ADT) with higher chances of turning out to be metastatic.

Robert Lacaze, executive member of the pharmaceuticals division as well as strategic business head at Bayer stated that Nubeqa’s approval had opened gates to a new therapy that aids in extending MFS besides allowing physicians more flexibility in treating men having nmCRPC.

As per Matthew Smith, MD, Ph.D., director at the Massachusetts General Hospital Cancer Centre in Boston for Genitourinary malignancies program, The approval of Nubeqa has opened the gates for a new option in prostate cancer treatment. He added that the objective of the treatment was to curb the spread of cancer besides controlling therapy side effects as Patients usually do not exhibit any typical symptoms of MFS.

Stomach Cancer – Causes, Symptoms, Diagnosis And Treatment

Stomach cancer is one of the most common cancers in India particularly in northeastern parts of India. Hospital-based data from Mizoram shows around 30 percent of the admitted cancer patients suffering from gastric cancers.

Alike other cancers symptoms of stomach cancer are not apparent in the beginning and are similar to symptoms like common health conditions like flu and more. The symptoms of stomach cancer include –

Stomach Cancer

  1. Unexplained Weight loss

  2. Abdominal Pain

  3. Nausea and vomiting

  4. Discomfort in the area above the belly button

  5. Bloating post small meals

  6. Indigestion and heartburn

  7. Anemia

  8. Blood in stool

As you can see, the aforementioned symptoms aren’t really a reliable indication of cancer. A stomach virus or ulcer could also have these symptoms. The indicative symptoms only occur once the cancer is at an advanced stage.

Risk Factors

Risk factors for stomach cancer include the genetic history of cancer and smoking as well. Helicobacter Pylori bacterium infection is also one of the major causes of stomach cancer. Having said that, though many people who do have the germ inside them do not get cancer.

Stomach Cancer Treatment

Treatment is based on the diagnosis and could involve surgery, chemotherapy, or radiation therapy. Usually, the treatment involves either curing the condition if it is in the early stages or controlling or relieving the symptoms. If the objective is cure then the treatment also concentrates on relieving the side effects. If the objective is to keep cancer under control, the treatment involves relieving symptoms that affect the quality of life like eating problems, pain, and bleeding. A second opinion is always advisable when it is about cancer.

Stomach Cancer Prevention

Though cancer is not preventable as such what you can do is only manage the risk factors through a balanced diet rich in fiber and citrus fruits, exercise, and physical activity.

Also Read: Stomach Worms in Children

Biopsy – All You Need To Know About Biopsy

For a variety of cancers the only way to provide a definite diagnosis about a condition is to carry out biopsy. The procedure involves the removal of a sample of cells or a tissue from the body for a closer examination.

Biopsy - Types of Biopsy

Types of Biopsy

Needle Biopsy – This type of biopsy is used mostly for diagnosis of cancers that can be felt through the skin. These include enlarged lymph nodes as well as breast nodes

  • Fine needle aspiration A needle and a syringe is used to get a sample from either breast lump or thyroid.

  • Vacuum assisted biopsy – There’s a suction device is used to extract more amount of fluid at a time so that the needle does not have to be inserted many times.

  • Image guided biopsy - Image guided biopsy uses a combination of imaging procedures like computerized tomography (CT), X-ray, sonography or MRI.

  • Core needle biopsy – It uses a needle that is larger with a cutting tip to draw the sample column of tissue.

Endoscopic Biopsy- An endoscope is used for taking tissues from the stomach during endoscopy. An endoscope is a tube with a camera at its end.

Incisional Biopsy – It involves taking a small part of skin

Excisional Biopsy – It involves taking a big part of the tissue/ tumor and requires a

Skin Biopsy – The procedure is carried out in order to check for lesions, rashes, growth, moles and lesions. The doctor takes samples of your skin surface with the help of a razor.

Punch Biopsy – A small instrument is used to punch a hole in the skin in order to get a sample.

Bone Marrow Biopsy – This biopsy involves taking samples of the bone marrow to check for cancerous or non-cancerous cells causing blood problems. A sample of the bone marrow is taken for diagnosis around cancers like lymphoma, leukemia and more.

Yes, biopsy does sound freaky but with the advanced procedures in place, its mostly a low risk as well as pain free procedure. So, if you are to undergo a biopsy procedure soon, do not panic. Stay calm, there’s nothing to worry about it.

*Sourced from the Internet

Just know about VIMS &RC

Effects Of Cancer On Mental Health

Even today after so much advancement in the field of healthcare and medicine and so much rewarding research around cancer, it still remains a dreaded disease for people. Yes, innovation and research in the cancer field have brought about a lot of hope in terms of increasing longevity and improvement in quality of life, even today when we hear of been diagnosed with cancer, we do get goosebumps or a shocker. These days’ people have become quite vocal about disclosing the diagnosis to people and sharing their experiences, particularly celebrities are quite vocal about it. Even though, different people experience differently depending upon their individual mental health.

Most of us feel that having cancer means a physical condition that is life-threatening, causes fatigue, hair loss, and nausea. But, beyond physical issues, comes the mental health issue which we are not able to see. Some might tell about it while some may not but the fact of the matter remains that hearing the news does not get easier for anyone. There comes some point in life where most cancer patients slip into depression. Here are the most common feelings that storm through the minds of cancer survivors –

cancer Hospital in Bangalore

DEPRESSION – As per the National Cancer Institute, depression is known to affect around 15 to 25 percent of the cancer population. The condition is a result of diagnosis itself primarily. Other reasons for depression include cancer side effects, anxiety around the future with cancer, change in the image of self, to name a few. Depression is not the same as feeling sad, it comes with symptoms like fatigue, emptiness, mood swings, worthlessness to name a few.

GRIEF – Grief is not limited to the cancer patient but to his family and relatives as well for the period through the cancer battle. There is this term called anticipatory grief, apparently a mix of emotions that come when we live with a personal loss experience that results in grieving. This same grief is experienced by cancer patients and their relatives. Although it is normal to experience grief in such times, grieving alone isn’t advisable.

ANXIETY – Anxiety is one of the most common problems that cancer patients face around their future prognosis, future reports, treatment-related issues to name a few. The cancer community has also coined a special work for anxiety around future scans, calling it scanxiety.

All these mental health issues do need to be looked into and consulting a mental health specialist or therapist surely does help. Well, it important to understand that if mental health is better, the healing is faster and even the quality of life.

Risk of Breast Cancer in Trans Women Post Hormone Therapy Escalates To Over 45 Times

A study has found that trans-women undergoing gender change procedures increase their risk of getting breast cancer by over 46% as compared to men. The study was carried out on over 2000 trans-women and it was found that after undergoing the sex-change procedures 1 in 200 came under the risk scanner of breast cancer as compared to less than 8000 in men.

Cancer hospital in Bangalore

The studies that were carried out earlier have shown that hormone replacement therapy (HRT) does increase the risk of breast cancer, particularly in women post-menopause. Suggestively, it would increase the risk in trans-women undergoing hormone treatment.

As a study involving 2260 women, 15 cases of invasive breast cancer came to light of that of women of over 50 years of age post 18 years on an average of hormone therapy. Dr. Martin Den Heijer from Amsterdam University Medical Centre says that the issues and side effects of hormone therapy are knowns are discussed also with the people who undergo treatment.

Though the risk for naturally born women is one-third less, the experts from the Netherlands said that not only the patients but even the doctors needed to be aware of the fact that injections of female hormones do have an increased threat.

In Britain, there has been a drastic rise in the number of operations and it’s around 250 per year presently as compared to 54 around 2000. The researchers were unclear though if some of the cases were genetic or due to lifestyle because one of their transgender woman studies did carry the BRCA gene mutation that leads to breast cancer. Besides, it also showed that transgender men were at a considerably lower risk as compared to the female population. The study that determined the same involved 1229 trans men of which four had invasive breast cancer have diagnosed at 47 years post 15 years of hormone treatment.

Cancer Vaccine that can Cure 97% of Tumor from Mice Approved for Human Trial

Yes, you read that right. As per researchers of Stanford University, a vaccine they tested on mice has worked well in curing around 97% of the tumors in mice and is ready for human trial. According to SFGate. the human trial is scheduled to be conducted on 35 people suffering from lymphoma before the year ends.

The study was earlier tested on mice with cancers ranging from colon, breast and lymphoma. The results were welcoming, because this treatment cured around 87 mice out of the 90. The best part is that tumors in some mice had spread through other parts of the body too and even then they could be cured.

Cancer Vaccine That can Cure 97% of Tumor from Mice Approved for Human trial

As per the regional director of breast surgery at North-well Health Cancer Institute in Westchester, New York, even if the news was exciting enough, the results on animals might not be the same as that on humans. So, there is still a long way to go before the treatment works for particularly cancers other than lymphoma, viz. breast and colon.

Though it is called a vaccine, technically it ain’t. It is more of an immunotherapy. It is still given the name of a vaccine for a reason that is does contain a vaccine like injection. Also, as per the American society of clinical oncology, cancer vaccines can be used for referring treatment of cancer and preventing it from coming back. This vaccine involves the injection of the vaccine into the existing tumor. It does the role of reactivating the T cells. These T cells are responsible for infiltrating and attacking the cancer cells. But, as the tumor increases, the cancer tells suppress these T cells.
Immunotherapy is not something new though. It has been in practice for quite some time. A treatment called CAR t-cell therapy has been already approved some time back for leukemia as well as lymphoma. This therapy is about removing certain immune cells from the body and genetically engineer these cells so that they become capable of fighting cancer.

But, the advantage of this therapy over CAR T-cell therapy is that nothing from the body is to be removed or customized. Here it’s just targeted therapy where the doctors will be concentrating and attacking specific targets.

Though this study is one step forward in the direction to treat cancer but still it’s a long way to go.

Vydehi Institute of Oncology & Research Centre is one of the first centers in India to commission IGRT (Image guided radiation therapy) with respiratory gating apart from having other radiation equipment like High Dose Rate Brachytherapy (HDR).

*Source from the Internet

One Blood Test to Diagnose 8 Different Cancers

A recent study has revealed the ability of one blood test to detect as many as eight types of cancers with perfection. The study was carried out by a team of researchers at the John Hopkins University of Medicine, Baltimore, and even published in the Science Journal. The study was carried out over 1000 people with the disease and showed high specificity and sensitivity as well.

Today, even with many innovations and advances in science, Cancer is still not having a cure. While research is on, the estimated death toll by 2030 across the world due to cancer can go up to a staggering 8-13 million range.

One Blood Test to Diagnose 8 Different Cancers

Because, the cure is still to be found, the effectiveness of the treatment is limited to restricting the spread of the cancer cells and increasing life span. An early diagnosis is always beneficial in cancer but sadly, by the time you become aware of cancer in your body, it is too late and its spreads to other parts. The reason is the lack of advanced tools for diagnosis. But, here’s some good news from the research team at John Hopkins University could crack the code to a simple way to detect cancer that too in the early stages.

The idea is to detect small fragments of mutated DNA as well as proteins that the cancerous tumors release in the bloodstream when they are formed, thus helping to detect cancer through a blood test. The researchers revealed that the new blood test has the ability to identify 16 gene mutations as well as 8 proteins linked to eight different cancer types.

The cancers include colorectal cancer, lung cancer, breast cancer, and five others that even today do not have routine screening tests for people with average risk namely pancreatic cancer, liver cancer, esophageal cancer, stomach cancer, and ovarian cancer.

As per Cristian Tomasetti, associate professor of oncology and biostatistics of John Hopkins University, the uniqueness of this classification method in observing different levels of Proteins together with DNA mutations in order to reach a final decision.

The Cancer SEEK test was performed on 1005 individuals in total and successfully identified 70% of the cancers with high sensitivity ranging from 33% in breast cancer cases and up to 98% in ovarian cancer cases. In the five cancers which do not have routine screenings, the test performed even better showing a sensitivity of 69% to 98%.

As far as specificity is concerned the range was 99% and out of the 812 people tested, it only showed seven false results. What’s more, the test was even able to detect the location of the tumor in over 80% of the patients.

As per the researchers, it will take further study to determine its efficacy as a routine screening test for cancer detection but the results are encouraging and definitely paves the way towards improving the quality of life of cancer patients through early detection.

Oral Cancer – Types – Risk Factors – Symptoms – Diagnosis – Stages – Treatment

The cancer that develops in the tissue of mouth or throat is known as oral cancer and belongs to head and neck cancer group. The cancer usually occurs in people over the age group of 40 and there are thousands of people suffering from oral cancer every year. The survival and treatment is based on the diagnosis and the stage of detection.

Oral Cancer types
1. Tongue Cancer
2. Lips Cancer
3. Gums Cancer
4. The floor of the mouth
5. The inner lining of the cheek
6. Hard and Soft palate

Risk Factors
Oral cancer is most common in people chewing tobacco in different forms like pipes, a cigar as well as in people who consume alcohol. Male are twice at risk of oral cancer compared to women. Besides, the following risk factors can cause cancers as well.
• The family history of oral or any other cancer
• Poor Nutrition
• Weak immune system
• Human papillomavirus (HPV) infection
• Chronic facial sun exposure

Oral Cancer

Symptoms
• A lump growth anywhere inside the mouth
• Bleeding from the mouth
• Trouble swallowing or wearing dentures
• Loose teeth
• A lip or mouth sore that does not heal
• A sore throat
• Red or white patches on lips or inside the mouth
• Jaw or tongue pain or stiffness

Diagnosis
The diagnosis can be done using either X-ray, CT Scan or an MRI scan. MRI’s can show highly accurate results on cancer of neck and head with the stage of it while PET scan can be done in order to check whether the cancer is reached to the other organs or lymph nodes. X-ray can help determine whether cancer has spread to chest, lungs or jaw. CT scan is also used to diagnose cancers in organs like lungs, neck, mouth, and throat.

Stages
There are four stages through which cancer progresses and the survival rate also varies based on the stage of detection of the cancer
Stage 1 – The tumor at this stage is around 2 cm or even smaller and the cancer is not yet spread to the lymph nodes. Survival rate at this stage is quite high
Stage 2 – The tumor is over 2 cm but under 4 cm in size and cancer hasn’t spread to the nodes. The survival rate is good if the cancer is detected at this stage
Stage 3 – This is a bit advanced stage where the tumor is over 4 cm and it hasn’t spread to the lymph node or is of any size and has spread to one of the lymph nodes. The survival rate is reduced at this stage
Stage 4 – This is the final stage and cancer has a tumor of any size that has spread to other lymph nodes as well as other parts of the body.

The survival rate for over 60% of people with oral cancer is said to be up to five years or more. The earlier the diagnosis happens, the more is the rate of survival and hence it is the most for localized cancer (83%), 64% for cancer that has spread to lymph nodes and 38% for last stage cancer.

Treatment
The treatment of oral cancer depends on the diagnosis and the type, location, and stage of cancer.
The treatment includes –
Surgery – The initial treatment involves removal of the cancerous tumor and lymph nodes. If required some other tissues might be removed from the neck and mouth.
Chemotherapy – This therapy involves removal of the cancerous cells using drugs. The therapy is carried out on an outpatient basis, wherein the medicine is provided orally or via (IV).
Radiation Therapy – The therapy is a process of two to eight weeks wherein the doctor projects radiation beams at the tumor once or twice a day. For advanced stage cancers, a mix of chemotherapy and radiation therapy is carried out.
Targeted Therapy – Targeted therapy is another form of therapy which works well will containing the growth of cancer cells. The drug binds with specific proteins on cancer cells in order to interfere with their growth.

Cancer treatment can take a toll on your diet making it difficult to eat and swallow. Hence, it is important that you discuss your nutrition with the doctor which provides you with all the need nutrients and is even painless for you to an extent.

Vydehi is one of the best cancer hospital in Bangalore, recently vims started VOICE – Vydehi Oncology Institute and Center of Excellence.

Prostate Cancer – An Overview

This cancer occurs in the male reproductive system to the prostate which is a gland that is just outside the bladder around the male urethra. This is one of the most common forms of cancer that occurs in men usually above 50 years of age. The people who have fathers or brothers diagnosed with prostate cancer at a younger age are at more risk of getting this cancer.

Here is a run down through the symptoms diagnosis treatment and survival span for patients suffering with prostate cancer. Prostate cancer consists of adenocarcinoma cells that originate from the glandular tissue. So, even if the cancer spreads through the bones, it is not called bone cancer but is known as prostate cancer metastatic to bones. Commonly prostate cancer metastasizes to the lymph nodes located in the pelvis and also to the bones.

prostate cancer

Risk Factors
As for the cause of prostate cancer, it is yet to be known though genetic factors are known to be responsible for the same. Though research is still on to figure out the exact cause of the condition.

Symptoms
Prostate cancer patients exhibit the following symptoms which mainly include urinary issues
1. Hesitancy or difficulty in starting
2. Nee to put stain for urinating
3. Decrease in force of urine
4. Intermittency or irregular flow of urine
5. Frequent bathroom visits
6. Dribble
7. Burning or pain during urinating
8. Erectile dysfunction
9. Painful ejaculation
10. Blood or semen in urine
11. Lower back or pelvic or abdominal pain
12. Unexplained weight loss, swelling in lower extremities and bone pain

Diagnosis
Prostate cancer screening needs to be done at regular intervals particularly after 40 or 45 if you have it in the genes. The testing involves prostate specific antigen (PSA) test and digital rectal examination. Though it has its own pros and cons hence it important to consult an urologist before doing such screenings.
If the PSA is abnormally high, or there is an abnormal area felt during rectal examination, the risk is raised.
Prostate biopsy can help confirm the possibility of having prostate cancer

Treatment
The treatment procedure involves observation of the cancer, monitoring it continuously, surgery also known as radical prostatectomy, radiation therapy, chemotherapy, hormone therapy as well as other therapies in order to limit the growth of cancer cells.

There are a lot of cancer deaths in the world but if timely diagnosis is carried out you can increase the survival rate and avoid deaths that are caused due to detection at the last stages.

Vydehi is one of the best cancer hospital in bangalore, recently vims started VOICE – Vydehi Oncology Institute and Center of Excellence.

Cancer Can Now Eliminate Tumors In Mice

A recent study by Stanford researchers have states that on activating T cells in Tumor, you can eliminate even distant metastases in mice. The researchers carried out the research in mice by injecting minimal quantity of two immune stimulating agents into solid tumors present inside mice. The researchers added that the idea could work well even on distant metastases and a variety of cancers as well.

Cancer Can Now Eliminate Tumors In Mice

The researchers further added that this therapy could turnout to be inexpensive comparatively and almost without any adverse side effects. The best part of this new finding is that the use of two agents together helps eliminate all the tumors in the body without a targeted approach to immune specific targets or wholesale activation of the immune system.

The development of the first of a kind monoclonal antibody, known as rituximab has been approved for cancer treatment in human beings. This approach makes use of small quantity of two agents in order to stimulate the immune cells within the tumor itself. The one time application of the same has displayed amazing results by eliminating all tumors in the studied animal. The method apparently reactivates the cancer specific T cells after the agents are injected in microgram amount into the tumor. Some tumor specific T cells also leave the place where they are injected, find other similar tumors in the body and eliminate them. The results have been awe-inspiring because out of the 90 mice 87 have been cured completely.

Now, the clinical trial involving humans is to begin. Initially 15 patients with low grade cancers are going to be experimented upon and if the results are as desired then the clinicians are aiming to inject the two mentioned agents in solid tumors before the surgical removal of them in order to prevent relapse of the same. As per the researchers, there is no limit on the type of cancer that could be treated using this technique as long as it can be infiltrated by the immune system.

The expected results of the test might as well pave the path to inexpensive cancer treatment therapy with astounding results.

*source from internet