Vydehi Institute of Medical Sciences
Biochemistry

Biochemistry Research

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Research

  • Dr.Raghavendra- Incidence &Prevalence of Type-II Diabetes Mellitus in those with impaired fasting glucose among teaching faculty of VIMS and RC

  • Dr.Shrabani Mohanty-Study on role of Magnesium in cerebrovascular accident patients.

  • Dr.Shailaja-Biochemical markers of Multiorgan damage in new borns with perinatal asphyxia

  • Scientific Papers:

    1. Kulkarni Sweta, Wilma Delphine Silvia CR, Raghavendra D.S. Evaluation of Serum CRP and Oxidative stress as cardiovascular risk predictors in PCOS. Biomedicine: 2011; 31(2):225-230.

    2.  Mangala N. Sirsikar, Raghavendra DS, Wilma Delphine Silvia CR. “Evaluation of  C-reactive Protein and Sialic acid as a predictor of Systemic inflammation in chronic   obstructive pulmonary disease” (Biomedicine Under review)

    1. Suprava Patel, Shrabani Mohanty, Manaswini Mangaraj, Prakash Chandra Mahapatra. Oxidant – antioxidant status in oligospearmic infertile males. Indian journal of Medical Biochemistry 2007; 11(1): 46 – 52.

    2. Rachita Nanda, Shrabani Mohanty, Manaswini Mangaraj, Prakash Chandra Mahapatra. Serum uric acid, lipid profile peroxidation status in patients of essential hypertension. Indian Journal of Medical Biochemistry. 2008; 12 (1): 49-54.

    1. Roopa Murgod, Ranjini CY, Wilma Delphine Silvia CR. A comparative study of Hepatic biochemical parameters between Vivax and Falciparum Malaria. Biomedicine: 2011; 31(2):185-188.

    2. Roopa Murgod, Sultana F, Venkatesh T. Development of reference ranges for Biochemical parameters of Liver and Renal functions in Bangalore city population. Biomedicine: 2009; 29(4):357-359.


    1. Benerjee, Amar kumar, BharatKumar, Madhusudan, Jose Jacob, Sudhakar Nayak et al. Determination of absolute hydrogen peroxide concentration by spectrophotometric method”. Current science vol.83,10, 25 November 2002,(1193-94).

    2. Pragathi, P., BharathKumar, P.V., Amar Kumar P., Ramakanth Reddy, M., Sravani, V., Neeraja, J.,Reeba Mary Eapen, Gopalakrishna, K. Evaluation Of Serum Adenosine Deaminase and 5'-Nucleotidase Activities As Probable Markers In Ovarian Cancer”. Indian Journal of Clinical Biochemistry, 2005, 20 (2) 195-197.

    3. Christopher R, Nagaraja D, Kruthika-Vinod TP, BharatKumar V. Prevalence of methylene tetrahydrofolate reductase gene C677T polymorphism and its association with Cerebral Venous Thrombosis in South Indians.J. Neurol Sci, Supple 1, 2005, s390.

    4. PS Bindu, AB Taly, Rita Christopher, BharatKumar PV. et al. Cholesterol Ester Storage Disease with Unusual Neurological Manifestations in Two Siblings. A Report from South India. Journal of Child Neurology.2007 Dec; 22(12):1401-4.

    5. Nagaraja D, Noone ML, Bharatkumar VP , Christopher R. Homocysteine, Folate And Vitamin B12 In Puerperal Cerebral Venous Thrombosis. Journal of Neurological Sciences 2008 Sep 15;272(1-2):43-7. Epub 2008 Jul 10.

    6. VP.Bharatkumar, D. Nagaraja, S K. Shankar, Rita Christopher, MD Hyperhomocysteinemia and MTHFRC677T homozygosity in a vegetarian male with sino venous thrombosis of brain. J Clin Neurosci. 2009 Oct;16(10):1380-1. Epub 2009 Jul 9.

    7. Wilma Delphine Silvia CR, BharatKumar PV.  Saga of Ghrelin: A mini Review (Asian BioMedicine vol 4, No.6 December 2010 855-860)

    8. BharatKumar PV, Wilma Delphine Silvia CR, Bhanu Prakash, Santosh KV Steatocystoma Multiplex with Oligidontia – A Clinical Report (Indian Journal of Clinical Practice, Vol. 22, No. 2, July 2011)

    9. BharatKumar PV, Nagaraja D, Rita Christopher. Hyperhomocysteinemia and methylene tetrahydrofolate reductase C677T polymorphism in cerebral venous and sinus thrombosis. (J Clin Neurosci. under review)

    10. BharatKumar PV, Wilma Delphine Silvia CR, Nitin. Migrelepsy : A Clinical      report (Indian Jounal of Clinical Practice Under review)

    11. Wilma Delphine Silvia CR, Swetha Kulkarni, BharatKumar PV. Mitochondrial
    DNA disorders. (BioMedicine Manuscript in progress)

    Dr. Kulkarni Sweta, PG student:

    1. Kulkarni Sweta, Wilma Delphine Silvia CR, Raghavendra D.S. Evaluation of Serum CRP and Oxidative stress as Cardiovascular risk predictors in PCOS. Biomedicine: 2011; 31(2):225-230

    Dr. Mangala N. Sirsikar, PG student:

    1. Mangala N. Sirsikar, Raghavendra DS, Wilma Delphine Silvia CR. “Evaluation of C- reactive Protein and Sialic acid as a predictor of Systemic inflammation in chronic obstructive pulmonary disease” (Biomedicine Under review)

    Achievements:
    Dr. D.S. Raghavendra, Professor &Head was appointed as

    1. Member of Board of studies for Pre-clinical for RGUHS, Bangalore during 2007-09.
    2. Member of Board of studies for Allied health sciences for RGUHS, Bangalore during 2007-09.
    3. Member of LIC team for RGUHS, Bangalore during the year 2010 for PG courses at st. Johns Medical College.
    4. Guest speaker at Association of medical biochemistry karnataka chapter, at Rajarajeswari Medical College & Hospital, B'lore. 10-12th sep.2015

    List of On-going Projects:

    Project 1:

    “Prevalence & Detection of Type II Diabetes mellitus in teaching Staff of VIMS & RC”
    Principal Investigator: Dr. Dr. Raghavendra DS
    Co Investigators:          Dr. Venkata Bharath Kumar P
    Research assistant:     Dr. Shailaja, Dr. Roopa Murgod

    Project 2:

    “A Study on the role of Magnesium in Cerebro Vascular Accident patients”
    Principal Investigator: Dr. Shrabani Mohanty
    Co Investigators:         Dr. Somashekhar, Prof& Head, Dept of Medicine
    Dr. Venkata Bharath Kumar P, Dr. Roopa Murgod

    Project 3:

    “The effect of Yoga practices on lipid profile and other parameters in health and disease.”
    Principal Investigator : Dr. D.S. Raghavendra                   
    Co-Investigators :    Dr. Venkata Bharath Kumar, Asst. Professor, Dept. of Biochemistry
    Ms. Vismayee, Vydehi Yoga Centre
    Dr. Harish Babu, Asst. Professor, Dept. of Medicine

    Project 4:

    “Cardiovascular risk screening in IT population of Bangalore”
    Principal Investigator: Dr. Shailaja, Associate Professor, Dept. of Biochemistry
    Co- Investigator          :  Dr. Murali Mohan  Professor, Dept. of Medicine

    List of Completed Projects:

    1. Study of biochemical Markers in chronic obstructive pulmonary disease.

    Principal worker             : Dr. Mangala Sirsikar, Post Graduate student
    Guide                                 : Dr. D.S. Raghavendra, Prof. & HOD, Biochemistry
    Collaborating Department: Dept. of TB & Chest, VIMS & RC

    1. Evaluation of serum C- Reactive protein and oxidative stress as cardiovascular risk predictors in polycystic ovarian syndrome


    Principal worker             : Dr. Swetha Kulakarni, Post Graduate student
          Guide              : Dr. Wilma Delphine Silvia, Professor, Biochemistry

    List of Latest Equipment:

    1. Blood Gas Analyser – AVL
    2. Beckman Synchron CX5 Pro
    3. Beckman Unicel DX 600
    4. Beckman Immage 800
    5. Beckman Access 2
    6. Bilirubinometer
    7. Centrifuge Beckman
    8. Electronic Balance -shimadzu
    9. Deionizer
    10. Deep Freezer – 200
    11. Walk in Cold Room 40
    12. Millipore water purification system
    13. RO water supply system
    14. Boiling Water baths, with lids having 8-12 holes
    15. Chemical Balance
    16. Vortex Mixer
    17. Constant temperature water bath
    18. Vacuum pump
    19. Colorimeter
    20. Refrigerators
    21. Centrifuge -Remi
    22. pH meter
    23. Homogenizers
    24. Electrophoresis apparatus with power supply for paper, Page, Agarose
    25. Desiccators
    26. Weighing Machine
    27. Incubator
    28. Heating Mantle
    29. Micro centrifuge
    30. Spectrophotometer
    31. TLC set
    32. Hot air oven
    33. Magnetic Stirrer
    34. PCR Machine
    35. Cooling centrifuge

    LIST OF ON-GOING PROJECTS IN THE DEPARTMENT OF BIOCHEMISTRY:

    1. TITLE :  Prevalence of type II diabetes mellitus and incidence of type II diabetes mellitus in those with impaired fasting glucose among teaching faculty of VIMS & RC, Bangalore
    a) Principal Worker:

    Dr. D.S. RaghavendraProfessor & Head, Dept. of Biochemistry

    b) Co-workers :
    Dr. P.V. Bharath Kumar          Associate Professor, Dept. of Biochemistry
    Dr. Minu Mary Mathew           Assistant Professor, Dept. of Biochemistry

    2. TITLE : The effect of Yoga practices on lipid profile and other parameters in health and disease.

    a) Principal Worker :
    Dr. D.S. Raghavendra              Professor & Head, Dept. of Biochemistry

    b) Co-workers :
    Dr. P.V. Bharath Kumar          Associate. Professor, Dept. of Biochemistry
    Ms. Vismayee                          Vydehi Yoga Centre
    Dr. Harish Babu                       Asst. Professor, Dept. of Medicine

    c) Collaborating Department: Dept. of Medicine, VIMS & RC

    3. TITLE : Cardiovascular risk screening in IT population of Bangalore

    a) Principal Worker :
    Dr. Shailaja                                          Professor, Dept. of Biochemistry

    b) Co-workers :
    Dr. Murali Mohan                                Professor, Dept. of Medicine

    c) Collaborating Department: Dept. of Medicine, VIMS & RC

    4. TITLE : A study of prevalence of thyroid dysfunction in Type 2 Diabetic patients
    a) Principal Worker :
    Dr. D.S. Raghavendra              Professor & Head, Dept. of Biochemistry
    Dr. ShrabaniMohanty              Professor, Dept. of Biochemistry

    b) Co-workers :
    Dr. Venkata Bharat kumar       Associate Professor, Dept. of Biochemistry
    Dr. RoopaMurgod                    Associate Professor, Dept. of Biochemistry
    Dr. Murali Mohan                    Professor, Dept. of Medicine ,

    c) Collaborating Department: Dept. of Medicine, VIMS & RC

    5.  TITLE : Identifying Molecular Mechanisms and  actions of Methotrexate drug in Psoriasis patients 

    1. Principal Worker :

    Dr. Venkata Bharat kumar Associate Professor, Dept. of Biochemistry

    1. Co-workers :

     

    Dr. BhanuPrakash                          Professor, Dept. of Dermatology
    Dr. D.S. Raghavendra                    Professor & Head, Dept. of Biochemistry

    6. TITLE : Quantitative Phosphoproteomic to decipher signal transduction during clear cell  renal cell carcinoma
    a) Principal Worker :Dr. Venkata Bharat kumar        Associate Professor, Dept. of Biochemistry


    b) Co-workers :          Dr. D.S. Raghavendra              Professor & Head, Dept. of Biochemistry
    Dr.Sanjay                                             Associate Professor, Dept. of Urology

    7. TITLE : Role of cardiac troponin I and creatine kinase MB as a biochemical marker of myocardial damage in newborns in perinatal asphyxia.
    a) Principal Worker :
    Dr. Preethi N Swamy                          Post graduate, Dept of Biochemistry

    b)Guide :
    Dr. Shailaja                                          Professor, Dept. of Biochemistry

    8. TITLE : Study of serum total antioxidant capacity, copper and MDA in cervical cancer patients.
    a) Principal Worker :
    Dr. SaiqaRasool ShahPost graduate, Dept of Biochemistry

    b)Guide :
    Dr. ShrabaniMohanty              Professor, Dept. of Biochemistry

    9. TITLE : Study of thyroid hormone levels (T3, T4 & TSH ) in chronic alcoholic liver disease patients before and after treatment.
    a) Principal Worker :
    Dr. Jaswanth Kumar Papineni          Post graduate, Dept of Biochemistry

    b)Guide :
    Dr. D.S. Raghavendra              Professor & Head, Dept. of Biochemistry

    10. TITLE : Study of serum calcium, phosphate and magnesium in chronic kidney disease patients.
    a) Principal worker :
    Dr. Deepthi                                            Post graduate, Dept of Biochemistry

    b)Guide :
    Dr. D.S. Raghavendra              Professor & Head, Dept. of Biochemistry

    11. TITLE : Estimation of serum ferritin and thyroid levels in women with chronic hair loss.
    a) Principal Worker :
    Dr. Shailaja                                          Professor, Dept. of Biochemistry

    12. TITLE : Association of vitamin B12 and folic acid deficiency in children with iron deficiency anaemia in a tertiary care support.
    a) Principal Worker :
    Dr. Shailaja                                          Professor, Dept. of Biochemistry

    The above projects has been approved by college research committee and ethical committee

    List of Completed projects:

    1.TITLE : A Study on role of magnesium in cerebrovasuclar accident patients
    a) Principal Worker :
    Dr. ShrabaniMohanty                                      Professor, Dept. of Biochemistry

    b) Co-workers :
    Dr. RoopaMurgod                                Associate Professor, Dept. ofBiochemistry
    Dr. Somashekhar                                 Prof. & HOD, Dept. of General Medicine

    c) Collaborating Department: Dept. of Medicine, VIMS & RC

    2. TITLE : Study of serum calcium, magnesium and copper levels in patients with essential hypertension.
    a) Principal Worker :
    Dr. Asha. G                                          Post graduate, Dept of Biochemistry

    b)Guide :
    Dr. ShrabaniMohanty              Professor, Dept. of Biochemistry