Tag Archives: Mouth Bacteria and Gut Disease

Mouth Bacteria and Gut Disease – The Trigger

Now, this is not something that is news, but a fact rather – The bacteria present in the mouth do contribute to various different health conditions like ulcerative colitis, chrohn’s disease and inflammatory bowel disease (IBD) as well.

A research study carried out on mice got results that showed certain bacterias do commute down to the gut in the intestine and settle down there, causing chronic possible chronic inflammation. As per researchers, the study is at preliminary stage, but they sure see ray of hope wherein, there is every possibility in the future to treat diseases like gut and IBD by finding ways to target the bacteria residing in the gut.

Mouth Bacteria and Gut Disease

Though, there have been studies in the past around oral bacteria, which suggest that they are not able to reside in the gut of a person because, other bacteria’s out class them. But, these bacterias are found in the gut of people who have been suffering from colon cancer, IBD and more. For detailed examination the researchers also studied the saliva samples of patients suffering form IBD and Crohn’s disease. The sampled bacteria were then transplanted into mice that were bred to not produce the gut bacteria on their own. The results were as desired the bacteria known as Klebsiella pneumoniae were able to sustain in the intestines of these germ free mice by activating immune cells called T helper cells and also sparked an inflammatory response. But, these same bacteria failed to survive when they were injected into the gut of different type of mice with balanced level of gut bacteria. They could only sustain there if these mice were fed with certain antibiotics. The researchers also trying injecting the K pneumoniae to the mice that prone to colitis or inflammation of colon genetically. The mice did persist there and caused severe inflammation. They also studied fecal microbiome and discovered that human poop of crohn’s and IBD suffering patients has more amount of Klebsiella species as compared to healthy people.

The researchers hypothesis around gut bacteria is that in people with conditions like IBD or other gut conditions, the intestine inflammation creates an environment that favors mouth bacteria. After colonization in the gut these bacteria help in perpetuating chronic inflammation and gut microbiota dysbiosis. Therefore, according to them targeting these bacteria can help in providing strategy for treatment of various IBD and gut conditions in human kind as these bacteria could be termed as the good bacteria inside us.

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