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How Trojan Horse Treatment is the new Hope in Fighting Brain Tumor?

One of the common, as well as highly aggressive tumors of the brain, is the Glioblastoma multiforme. Once, the diagnosis is done, many patients die within a few months period itself. The survival rate for this tumor is as low as 6 patients out of 100 being able to live for 5 years period or more. This is one cancer that has shown a lot of resistance against treatments. One of the main reason behind the same is because this tumor invades the healthy brain tissues surrounding it, thus making impossible to remove it surgically.

The research was carried out by engineering nanostructures containing both conventional chemotherapy drugs namely cisplatin and gold. These nanospheres were released to the tumor cells were taken from patients suffering from glioblastoma, taken to the laboratory and grown followed by exposure to radiotherapy. The results were quite amazing and after 20 days, the tumor cells were totally destroyed without any proof of revival. The treatment was more effective than conventional chemotherapy because it enhanced the impact of it by helping gold to release electrons that caused damage to the DNA of the cancer cells and the overall structure as well.

Brain Tumor

This is a stepping stone in the treatment of aggressive brain tumor and as per the experts in Nanotechnology but work is still in progress before this treatment can be used for patients suffering with glioblastoma. The best part of the experiment was that it was carried out on tumors of glioblastoma patients, where the experts tested this approach drug resistant tumors that were evolving.

The study was carried out by Dr Colin Watts, a clinical scientist as well as honorary consultant Neurosurgeon at the Clinical Neurosciences and Mark Wellan, Professor of Nanotechnology and Fellow at St John’s College, University of Cambridge. This work of theirs is published in the Royal Society of Chemistry Journal call Nanoscale.

As per Professor Welland, their combined therapy seems to be highly effective particularly with live cell culture. This is definitely not the cure for cancer but throws light how nanotechnology can play a significant role fighting this aggressive cancer. Researchers also believe that this treatment procedure could be used for treating a variety of different and challenging cancer types.

The professor also harped upon the big advantage the nano scientists had by working with clinicians because they could ensure that this science does have a clinical relevance through their involvement. This further ensures that the idea can be realized and implemented beyond the labs due to its clinical impact.

PS *Sourced from the Internet

 Vydehi Institute of Oncology & Research Centre is a comprehensive cancer care unit. The seven storied building complex of the oncology center with a total area of 40,000 sq feet has 300 beds exclusively for cancer patients. It is the only center in India to have dedicated 16 slice CT scanner mated to IGRT machine for superior image guidance.

Zika Virus and Brain Cancer

One of the most dreaded diseases in India is Cancer and its various varieties. As on day there are a variety of treatments available to treat cancer through surgeries and therapies. But, we are yet to find a treatment that guarantees uprooting cancer from its root and even vaccines to avoid it altogether. Here’s some update on zika virus and its association with brain cancer.

Zika Virus and Brain Cancer

Most of us are aware of the havoc that Zika virus has been creating since its outbreak in the south african countries. But, we are less known of some new updates on the same. Researchers apparently have found out its usage in brain cancer treatment beyond its significant threat to the unborn children.

Though untested in humans yet, the results after testing on lab dishes and animals do reveal that could help treat brain cancer. Its already known that in infants and fetus, the zika targets the brain stem cells which are found in abundance in their brain cells and kills them. This usually increases the chances of neurological issues in new borns infected with zika. But, zika is not able to target adult brains with the same effectiveness. Comparatively, the effect is less severe plus these viruses have the ability to target and kill the lethal glioblastomas, stem cells which are lethal and are not affected by chemotherapy or radiation therapy and trigger the cancer again post treatment.

This research had further created rays of hope in treating brain cancer but requires further studies and tests to be carried out on animals before trying out on humankind. The reason mainly revolves around safety issues related to zika virus. Presently, there are research groups that are also testing other virus like polio, herpes and more in order to target glioblastomas. The use of zika virus as a brain cancer healer aide might require quite some time and a lot of further testing before it hits the cancer hospitals across the world.

All You Need To Know About throat Cancer

Though we as humankind haven’t had a breakthrough in completely treating every kind of cancer or a vaccine in protecting ourselves from it, if we are alert enough, there is every possibility of catching hold of it at an early stage so as to treat it well before it goes out of control. One such cancer type is throat cancer. As goes its name, it is the cancer of throat and affects the pharynx as well as the larynx or voice box. While the pharynx is located above the esophagus and larynx and below the nasal cavity, the larynx is located in the front of the neck.

Throat-Cancer-causes-symptoms

The risk factors associated with throat cancer include –
Sexually transmitted virus known as human papillomavirus (HPV)
Addictions like tobacco, gutkha, alchohol and smoking
A diet free from fruits and vegetables
Gastroesophageal reflux disease (GERD)
Genetics viz inherited defects in certain genes
Aesbestos exposure
Dental hygiene issues
Throat Cancer Stages

There are three different stages in throat cancer. If detected at an early stage throat cancer is pretty much treatable with surgery and radiation.

Symptoms of Throat Cancer
Symptoms of throat cancer include blood coughing, swelling in lymph nodes, trouble swallowing and more. Other than that some of the potential symptoms of cancer include the following
Cough that rarely goes away
Constant Throat Clearance
Unexplained Weight loss
Soar Throat
Ear pain
Hoarseness

Stages of Throat Cancer
The levels of throat cancer are spread across four stages 0 to 3.
Stage 0 – This is the earliest stage of caner wherein the tissue isn’t affected any other areas except your throat.
Stage 1 – The cancer has not affected any other areas beyond the throat but the size of it is less than or equal to 7 cm.
Stage 2 – The size of the throat has crossed 7 cm but still hasn’t invaded other organs
Stage 3 – The cancer has spread upto nearby organs and tissues.
Stage 4 – The cancer has spread to distant organs as well as lymph nodes

Throat Cancer Diagnosis
For diagnosis the doctor or oncologist may ask to do a biopsy or a fine needle aspiration. The biopsy recommended could be either a conventional biopsy or an endoscopic biopsy. The doctors would further recommend a few tests for determining the stage of your cancer. These include CT scan, PET scan or a MRI test.

Treatment of Throat Cancer
The treatment would be typically based on the stage of the cancer. It could include removal of the tumor and radiation and chemotherapy later on. It is a prolonged process and not a matter of few days. Repeated tests would have to be carried out to determine how successful the surgery, the radiation or chemotherapy therapy have been. Based on the reports the trajectory of the further treatment would be derived.

Recovery Issues
Throat cancer complications after the surgery and treatment could include disfigurement of neck and face primarily. This though can be fixed to a certain extent through surgery. The other issues that a patient may face during recovery includes breathing and swallowing difficulty, trouble while speaking and skin hardening around the neck.

Cancer of any kind is a condition which if caught hold of early on can be treated and many a times completely eradicated but this requires you to be alert and keep a eye on your health like a hawk. Regular health checkups are advisable for the same.

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Gut Bacteria as an Anti – Aging Agent – An Overview

Gut Bacteria as an Anti - Aging Agent

Gut bacteria in the years to come can help reduce the effects of aging, rather could be of great help in slowing down aging process. This could be possible with the help of supplements derived from gut bacteria. These bacterial genes and compounds can also decrease the rate of tumor progression inside our body besides amyloid beta accumulation, a compound known to be related to Alzheimer’s disease, as per University of Texas Health Science Center.

The scientists and researchers fraternity is well aware that the body interacts with millions of microbes called the microbiomes, inside the body. These microbiomes tend to influence the metabolic and cognitive activities as well as the aging process. Scientists at the Huffington Center are investigating on the possibility of importance of genetic composition of microbiomes for long life.

Experimentation
An experiment was carried out on laboratory work C. elegans as doing it on mammals was quite challenging technically. The characteristics of C. Elegans are very much similar to that of human biology and are simple, transparent organisms with a short life span of upto 3 weeks. This aids in rapid collection of data.

The experiment involved deleting one gene each from the 4000 genes at a time in an e.coli bacteria library to study the effects of each one. The researchers fed each individual mutant bacteria to the C. Elegans and then observed the worm’s life span closely.

As per the researchers, out of 4000 bacterial genes that they tested, they deleted 29 of them and found that it increased the life span of the worms. Furthermore, they also noticed that, 12 of these bacteria restricted tumor growth besides amyloid-beta accumulation. Even purified colanic acid was provided to C. Elegans and showed increased life span in them besides fruit fly and other mammalian cells. They also found that colanic acid regulated the dynamics of cellular structures called mitochondria, responsible for providing energy to the cell.

Well, based on the research that has been carried out and is being carried out, the researchers affirmatively suggest that designing supplements of the bacteria or their compounds could help slow down the aging process.

VIMS – One of the Best Hospital in Bangalore

All You Need To Know About Lipomas

If you have seen some lumpy formations around your body of the size 1 cm – 2 cm then they could be lipomas. Lipoma is a lump formed under the skin from fat deposits. It is generally found in ages 40-60 years and areas may include neck, back or shoulders. They could occur in younger generations as well and on almost any part of the body.

Lipomas are generally slow growing tumors which are generally benign in nature. They might not grow also. As per doctors, they are rarely harmful and there is meager possibility of they turning malignant.

Lipomas

Detection
A lipoma is a fat tissue based tumor and is very soft to touch. Its just under the skin and rarely painful, but it could be. It is colorless, grows slowly and moves easily when you prod it with your finger.

Causes
As of now, there is not defined reason for causing Lipomas. Though, one of the most common reasons is genetic or heriditary factor.

Treatment
Though, a doctor may not suggest any treatment on lipomas as they are painless and non benign.
But, if you are uncomfortable with the lipomas as they might look ugly, then your doctor may remove it with a minor surgery that includes numbing the area around lipoma, creating an incision and removing it. Then stitching the incision. Alternatively Liposuction can be used for removal. Another option is steriod injections in and around the affected area in order to shrink the lipoma can be used. Steriods only help to an extend of shrinking them and not complete elimination.

Home Remedies
Some natural supplements have known to be very effective with fat deposits. This includes turmeric roots, dandelion roots and more. These are those detoxifying herbs that have to be consumed with a lot of water so as to aid in elimination of the toxins. You can even take in turmeric by adding a teaspoon every day in your milk.

There are a few natural oils that might just help in controlling lipomas. This includes tea tree, frankincense, castor oil, sage oil, to name a few. Simple add a half a teaspoon of oil in you regular hair oil and apply it to the affected areas twice a day. Castor oil can also be massaged at night before going to bed on and around the lipomas.

When you use home remedies, their effect is generally slow but steady. So, you need to have a lot of patience to see the results. Use the home remedies atleast for a month and if it does not seem to work then try some other remedy from the suggested ones as per suitability. Its not that natural remedies won’t work. They might just work for you if you keep calm and use them for a long duration of time. There are stories where natural remedies have been affective in treating lipomas. They do not have side effects, so you may as well try them out.

Vydehi Institute of Medical Sciences and Research Centre, Bangalore provides services in healthcare and education. Hospital provides free medical services. College offers Medical, Dental, Nursing and Paramedical courses