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Cancer Vaccine that can Cure 97% of Tumor from Mice Approved for Human Trial

Yes, you read that right. As per researchers of Stanford University, a vaccine they tested on mice has worked well in curing around 97% of the tumors in mice and is ready for human trial. According to SFGate. the human trial is scheduled to be conducted on 35 people suffering from lymphoma before the year ends.

The study was earlier tested on mice with cancers ranging from colon, breast and lymphoma. The results were welcoming, because this treatment cured around 87 mice out of the 90. The best part is that tumors in some mice had spread through other parts of the body too and even then they could be cured.

Cancer Vaccine That can Cure 97% of Tumor from Mice Approved for Human trial

As per the regional director of breast surgery at North-well Health Cancer Institute in Westchester, New York, even if the news was exciting enough, the results on animals might not be the same as that on humans. So, there is still a long way to go before the treatment works for particularly cancers other than lymphoma, viz. breast and colon.

Though it is called a vaccine, technically it ain’t. It is more of an immunotherapy. It is still given the name of a vaccine for a reason that is does contain a vaccine like injection. Also, as per the American society of clinical oncology, cancer vaccines can be used for referring treatment of cancer and preventing it from coming back. This vaccine involves the injection of the vaccine into the existing tumor. It does the role of reactivating the T cells. These T cells are responsible for infiltrating and attacking the cancer cells. But, as the tumor increases, the cancer tells suppress these T cells.
Immunotherapy is not something new though. It has been in practice for quite some time. A treatment called CAR t-cell therapy has been already approved some time back for leukemia as well as lymphoma. This therapy is about removing certain immune cells from the body and genetically engineer these cells so that they become capable of fighting cancer.

But, the advantage of this therapy over CAR T-cell therapy is that nothing from the body is to be removed or customized. Here it’s just targeted therapy where the doctors will be concentrating and attacking specific targets.

Though this study is one step forward in the direction to treat cancer but still it’s a long way to go.

Vydehi Institute of Oncology & Research Centre is one of the first centers in India to commission IGRT (Image guided radiation therapy) with respiratory gating apart from having other radiation equipment like High Dose Rate Brachytherapy (HDR).

*Source from the Internet

One Blood Test to Diagnose 8 Different Cancers

A recent study has revealed the ability of one blood test to detect as many as eight types of cancers with perfection. The study was carried out by a team of researchers at the John Hopkins University of Medicine, Baltimore and even published in the Science Journal. The study was carried out over 1000 people with the disease and showed high specificity and sensitivity as well.

Today, even with many innovations and advances in science, Cancer is still not having a cure. While research is on, the estimated death toll by 2030 across the world due to cancer can go up to a staggering 8-13 million range.

One Blood Test to Diagnose 8 Different Cancers

Because, cure is still to be found, the effectiveness of the treatment is limited to restricting the spread of the cancer cells and increasing life span. An early diagnosis is always beneficial in cancer but sadly, by the time you become aware of the cancer in your body, it is too late and its spread to other parts. The reason is lack of advanced tools for diagnosis. But, here’s some good news from the research team at John Hopkins University could crack the code to simple way to detect cancer that too in the early stages.

The idea is to detect small fragments of mutated DNA as well as proteins that the cancerous tumors release in the blood stream, when they are formed, thus helping to detect cancer through a blood test. The researchers revealed that the new blood test has the ability to identify 16 gene mutations as well as 8 proteins linked to eight different cancer types.

The cancers include colorectal cancer, lung cancer, breast cancer and five others that even today do not have routine screening tests for people with average risk namely pancreatic cancer, liver cancer, esophageal cancer, stomach cancer and ovarian cancer.

As per the Cristian Tomasetti, associate professor of oncology and biostatistics of John Hopkins University, the uniqueness of this classification method in observing different levels of Proteins together with DNA mutations in order to reach to a final decision.

The Cancer SEEK test was performed on 1005 individuals in total and successfully identified 70% of the cancers with high sensitivity ranging from 33% in breast cancer cases and upto 98% in ovarian cancer cases. In the five cancers which do not have routine screenings, the test performed even better showing a sensitivity of 69% to 98%.

As far as specificity is concerned the range was 99% and out of the 812 people tested, it only showed seven false results. What’s more the test was even able to detect the location of the tumor in over 80% of the patients.

As per the researchers, it will take further study to determine its efficacy as a routine screening test for cancer detection but the results are encouraging and definitely paves the way towards improving quality of life of cancer patients through early detection.

VIMS is one of the best cancer hospital in India, with 300 beds exclusively for cancer patients.Oncology department in the hospital has got qualified and well experienced doctors

How Trojan Horse Treatment is the new Hope in Fighting Brain Tumor?

One of the common, as well as highly aggressive tumors of the brain, is the Glioblastoma multiforme. Once, the diagnosis is done, many patients die within a few months period itself. The survival rate for this tumor is as low as 6 patients out of 100 being able to live for 5 years period or more. This is one cancer that has shown a lot of resistance against treatments. One of the main reason behind the same is because this tumor invades the healthy brain tissues surrounding it, thus making impossible to remove it surgically.

The research was carried out by engineering nanostructures containing both conventional chemotherapy drugs namely cisplatin and gold. These nanospheres were released to the tumor cells were taken from patients suffering from glioblastoma, taken to the laboratory and grown followed by exposure to radiotherapy. The results were quite amazing and after 20 days, the tumor cells were totally destroyed without any proof of revival. The treatment was more effective than conventional chemotherapy because it enhanced the impact of it by helping gold to release electrons that caused damage to the DNA of the cancer cells and the overall structure as well.

Brain Tumor

This is a stepping stone in the treatment of aggressive brain tumor and as per the experts in Nanotechnology but work is still in progress before this treatment can be used for patients suffering with glioblastoma. The best part of the experiment was that it was carried out on tumors of glioblastoma patients, where the experts tested this approach drug resistant tumors that were evolving.

The study was carried out by Dr Colin Watts, a clinical scientist as well as honorary consultant Neurosurgeon at the Clinical Neurosciences and Mark Wellan, Professor of Nanotechnology and Fellow at St John’s College, University of Cambridge. This work of theirs is published in the Royal Society of Chemistry Journal call Nanoscale.

As per Professor Welland, their combined therapy seems to be highly effective particularly with live cell culture. This is definitely not the cure for cancer but throws light how nanotechnology can play a significant role fighting this aggressive cancer. Researchers also believe that this treatment procedure could be used for treating a variety of different and challenging cancer types.

The professor also harped upon the big advantage the nano scientists had by working with clinicians because they could ensure that this science does have a clinical relevance through their involvement. This further ensures that the idea can be realized and implemented beyond the labs due to its clinical impact.

PS *Sourced from the Internet

 Vydehi Institute of Oncology & Research Centre is a comprehensive cancer care unit. The seven storied building complex of the oncology center with a total area of 40,000 sq feet has 300 beds exclusively for cancer patients. It is the only center in India to have dedicated 16 slice CT scanner mated to IGRT machine for superior image guidance.

A Technique To Destroy Cancer Cells Within Three Days

A new study has further raised the hope for treating cancer faster due to the easy technique which alters the structure of chromatin in cancer cells thus destroying them faster and in an easier way.

Now chromatin is formed from DNA that are wrapped around proteins and called Histones. Chromatin is responsible for regulating the genes that are switched on and off besides packaging the genetic code into the cell nucleus properly. In technical language you may put chromatin as the software if the genetics is termed as hardware.

A Technique To Destroy Cancer Cells Within Three Days

Though chromatin works for cancer cells in a way because it aids in their evolution and helps them adapt to cancer therapies, ultimately helping them survive and grow.
Cancer being a complex condition, individual behavior of genes does not make a difference but it all actually depends on the complex interplay of the thousands of genes. Hence, the researchers focused on chromatin for fighting cancer.

They developed the technique called Partial Wave Spectroscopic (PWS) microscopy, which allows real time monitoring of chromatin in living cells. They used this technique in cultured cancer cell and found that chromatin helps cancer cells evade treatment due to the specific packaging density linked with gene expression.

The more disordered and heterogenous the chromatin packaging density, the more ordered and conservative it is, the more are the chances of cancer cell death while responding to chemotherapy. Thus as per the discovery made, the researchers came to hypothesis that changing the chromatin structure and making it orderly can actually help in increasing cancer cells treatment vulnerability. Further study made them understand the fact that it was possible to modify the chromatin structure in the nucleus of the cancer cells by electrolytes.

The researchers tried combining two drugs one Celecoxib used for pain relief and Digoxin used for treating fibrillation as well as heart failure. Referring this combination as chromatin protection therapeutics (CPTs), they tested it on cancer cells in the lab with chemotherapy and the results according to the researchers were remarkable.

The researchers have also successfully replicated the finding in seven different cancer kinds which is a ray of hope in the cancer treatment.

Vydehi is one of the best cancer hospital in banglaore, recently vims started VOICE – Vydehi Oncology Institute and Center of Excellence

*Source form internet

Zika Virus and Brain Cancer

One of the most dreaded diseases in India is Cancer and its various varieties. As on day there are a variety of treatments available to treat cancer through surgeries and therapies. But, we are yet to find a treatment that guarantees uprooting cancer from its root and even vaccines to avoid it altogether. Here’s some update on zika virus and its association with brain cancer.

Zika Virus and Brain Cancer

Most of us are aware of the havoc that Zika virus has been creating since its outbreak in the south african countries. But, we are less known of some new updates on the same. Researchers apparently have found out its usage in brain cancer treatment beyond its significant threat to the unborn children.

Though untested in humans yet, the results after testing on lab dishes and animals do reveal that could help treat brain cancer. Its already known that in infants and fetus, the zika targets the brain stem cells which are found in abundance in their brain cells and kills them. This usually increases the chances of neurological issues in new borns infected with zika. But, zika is not able to target adult brains with the same effectiveness. Comparatively, the effect is less severe plus these viruses have the ability to target and kill the lethal glioblastomas, stem cells which are lethal and are not affected by chemotherapy or radiation therapy and trigger the cancer again post treatment.

This research had further created rays of hope in treating brain cancer but requires further studies and tests to be carried out on animals before trying out on humankind. The reason mainly revolves around safety issues related to zika virus. Presently, there are research groups that are also testing other virus like polio, herpes and more in order to target glioblastomas. The use of zika virus as a brain cancer healer aide might require quite some time and a lot of further testing before it hits the cancer hospitals across the world.

All You Need To Know About throat Cancer

Though we as humankind haven’t had a breakthrough in completely treating every kind of cancer or a vaccine in protecting ourselves from it, if we are alert enough, there is every possibility of catching hold of it at an early stage so as to treat it well before it goes out of control. One such cancer type is throat cancer. As goes its name, it is the cancer of throat and affects the pharynx as well as the larynx or voice box. While the pharynx is located above the esophagus and larynx and below the nasal cavity, the larynx is located in the front of the neck.

Throat-Cancer-causes-symptoms

The risk factors associated with throat cancer include –
Sexually transmitted virus known as human papillomavirus (HPV)
Addictions like tobacco, gutkha, alchohol and smoking
A diet free from fruits and vegetables
Gastroesophageal reflux disease (GERD)
Genetics viz inherited defects in certain genes
Aesbestos exposure
Dental hygiene issues
Throat Cancer Stages

There are three different stages in throat cancer. If detected at an early stage throat cancer is pretty much treatable with surgery and radiation.

Symptoms of Throat Cancer
Symptoms of throat cancer include blood coughing, swelling in lymph nodes, trouble swallowing and more. Other than that some of the potential symptoms of cancer include the following
Cough that rarely goes away
Constant Throat Clearance
Unexplained Weight loss
Soar Throat
Ear pain
Hoarseness

Stages of Throat Cancer
The levels of throat cancer are spread across four stages 0 to 3.
Stage 0 – This is the earliest stage of caner wherein the tissue isn’t affected any other areas except your throat.
Stage 1 – The cancer has not affected any other areas beyond the throat but the size of it is less than or equal to 7 cm.
Stage 2 – The size of the throat has crossed 7 cm but still hasn’t invaded other organs
Stage 3 – The cancer has spread upto nearby organs and tissues.
Stage 4 – The cancer has spread to distant organs as well as lymph nodes

Throat Cancer Diagnosis
For diagnosis the doctor or oncologist may ask to do a biopsy or a fine needle aspiration. The biopsy recommended could be either a conventional biopsy or an endoscopic biopsy. The doctors would further recommend a few tests for determining the stage of your cancer. These include CT scan, PET scan or a MRI test.

Treatment of Throat Cancer
The treatment would be typically based on the stage of the cancer. It could include removal of the tumor and radiation and chemotherapy later on. It is a prolonged process and not a matter of few days. Repeated tests would have to be carried out to determine how successful the surgery, the radiation or chemotherapy therapy have been. Based on the reports the trajectory of the further treatment would be derived.

Recovery Issues
Throat cancer complications after the surgery and treatment could include disfigurement of neck and face primarily. This though can be fixed to a certain extent through surgery. The other issues that a patient may face during recovery includes breathing and swallowing difficulty, trouble while speaking and skin hardening around the neck.

Cancer of any kind is a condition which if caught hold of early on can be treated and many a times completely eradicated but this requires you to be alert and keep a eye on your health like a hawk. Regular health checkups are advisable for the same.

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Gut Bacteria as an Anti – Aging Agent – An Overview

Gut Bacteria as an Anti - Aging Agent

Gut bacteria in the years to come can help reduce the effects of aging, rather could be of great help in slowing down aging process. This could be possible with the help of supplements derived from gut bacteria. These bacterial genes and compounds can also decrease the rate of tumor progression inside our body besides amyloid beta accumulation, a compound known to be related to Alzheimer’s disease, as per University of Texas Health Science Center.

The scientists and researchers fraternity is well aware that the body interacts with millions of microbes called the microbiomes, inside the body. These microbiomes tend to influence the metabolic and cognitive activities as well as the aging process. Scientists at the Huffington Center are investigating on the possibility of importance of genetic composition of microbiomes for long life.

Experimentation
An experiment was carried out on laboratory work C. elegans as doing it on mammals was quite challenging technically. The characteristics of C. Elegans are very much similar to that of human biology and are simple, transparent organisms with a short life span of upto 3 weeks. This aids in rapid collection of data.

The experiment involved deleting one gene each from the 4000 genes at a time in an e.coli bacteria library to study the effects of each one. The researchers fed each individual mutant bacteria to the C. Elegans and then observed the worm’s life span closely.

As per the researchers, out of 4000 bacterial genes that they tested, they deleted 29 of them and found that it increased the life span of the worms. Furthermore, they also noticed that, 12 of these bacteria restricted tumor growth besides amyloid-beta accumulation. Even purified colanic acid was provided to C. Elegans and showed increased life span in them besides fruit fly and other mammalian cells. They also found that colanic acid regulated the dynamics of cellular structures called mitochondria, responsible for providing energy to the cell.

Well, based on the research that has been carried out and is being carried out, the researchers affirmatively suggest that designing supplements of the bacteria or their compounds could help slow down the aging process.

VIMS – One of the Best Hospital in Bangalore

Cancer Treatment In India – The Current Scenario

Cancer is said to be one of the most common conditions amongst Indians and the sad part is India is listed as the third highest in cancer deaths in the world. The graph is pointing north and there is an estimated forecast of 25% increase by the year 2020. These are by far alarming figures. So, we need to be ready to fight the dreaded diseases and the first step to it is awareness about the conditions and its treatments.

Best Cancer Hospital in India

CANCER & ITS CAUSES
Every year over 6 lac people in India succumb to cancer in India. The most common cancers in India amongst men are oral, lung and throat cancers while the in women its breast cancer, cervix cancer and ovarian cancers. Even colon, prostate and kidney cancers are common types on cancers amongst the aged group. Apparently, causes of 25% of the cancers including bone, leukemia and more aren’t known yet. The majority cancer cases in India are that of oral cancers in men caused due to excessive intake of tobacco and its products. In women, cancer of the breast, uterus and kidney are caused due to obesity issues and genetic issues. Cervical cancer is a result of personal hygiene issues. The major causes of all remain tobacco use, obesity and cancer causing pathogens.

TREATMENT IN INDIA v/s ABROAD
Every other day, we wake up to the news of some celebrity catching cancer and also that most of them moving abroad for treatment. But, the words coming out of the horses mouth speaks a different story. Ask the leading oncologists and cancer specialists in India, and they say that India is one of the best destinations for cancer treatment. Primary reason is the cost factor. While comparing the treatment cost overseas in Dollars or Pounds, India almost 500% to 700% cheaper. Furthermore, due to globalization getting the latest medications in India is quick, at the most late by 3 months or so. India not only has expert oncologists, it is also equipped with the latest equipments and treatment facilities across cancer hospitals.

Best Cancer Hospitals in Bangalore

CANCER TREATMENT TYPES
The course of treatment depends upon the diagnosis of the condition and its current stage. The commonly used cancer treatments in India include Surgery, Chemotherapy, Radiation therapy, Immuno therapy, Hormone Therapy, Stem cell transplant, targeted therapy and precision medicine. The treatment might include one or combination of two or more treatments from the above, the common ones are radiation therapy, chemotherapy and surgery.
The latest in cancer treatment in India is Cyber Knife Surgery, a non invasive, pain free robotic radiation therapy with no side effects as such.

COST OF CANCER TREATMENT IN INDIA
The cost varies depending upon the cancer type, stage of cancer, the treatment type and hospital as well. While chemotherapy treatment includes traditional, standard or cytotoxic chemotherapy and radiation therapy includes systematic radiation therapy (SRT), Radioimmuno therapy, Instaoperative radiation therapy (IORT), to name a few. The cost depends on the type of the therapy and the number of the cycles. Well, radio therapy is said to be the most expensive of all.

VOICE - Vydehi Oncology Institute and Center of Excellence

Well, Cancer does cost, but there’s always a way out. Some NGO’s in India work towards financing patients through this life threatening condition. Even some hospitals in India do offer Cancer treatment facilities at subsidized rates. One such hospital is Vydehi Insitute of Medical Sciences, Bangalore. The oncology centre VOICE at VIMS offers cancer treatments at almost 30% less cost compared to any other cancer treatment institute or hospital in Karnataka. While offering Financial assistance for advanced treatments like IGRT/ IMRT/ SBRT/SRS /HIPEC to all, it also provides free cancer treatment to BPL card holders of Karnataka. Besides housing highly qualified and experienced oncologists and cancer specialists, this centre is lately equipped with a hi-tech radiation zone that features Versa HD -Stereotactic Precision Radiotherapy unit (Triple F). Featuring high precision beam shaping and tumor targeting, Versa HD is designed with new capabilities to provide a faster and more accurate treatment for a wide range of cancer conditions.