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Fda Approves Drug That Keeps Prostate Cancer At Bay For Long Time

Prostate cancer is one of the cancers that is common across the world. As per the statistics, it is known to be the second most common cancer in US and UK and sixth common cause of cancer deaths in the world. As far as India is concerned, the rates earlier were quite lower compared to other countries. But, the recent data shows a rise in cancer in India and mostly in urban areas particularly since the time.

prostate cancer

Now, males hormones are such that they only aid in worsening the symptoms and aiding its spread. Nubeqa or darolutamide is the new drug that is effective in controlling the cancer spread. It has the ability to increase the life expectancy rates by more than double.

As per the trial investigator and medical direction Neal Shore of Carolina Urologic Research Centre Prostate cancer particularly that’s spread across the other body parts is highly sensitive to the spread fast under the influence of male hormones like testosterone and testosterone metabolites.

Shore added the initial trials of the drug were a success as the tolerance was quite good events unique to ARIs that were observed in the earlier trials are not observed with darolutamide. Only that certain side effects like Nubeqa, rash and fatigue

He also added that the FDA approved the med only after it cleared the Phase III ARAMIS trial with positive results showing a rise in metastasis-free survival (MFS). Published in the New England Journal of Medicine earlier this year, had carried out the trial that involved 1509 participants who were provided with 600 mg of oral drug two times a day or a placebo alongside ADT. The randomized trial was multi-center, double blinded and placebo controlled on men with nmCRPC and under the treatment of androgen deprivation therapy (ADT) with higher chances of turning out to be metastatic.

Robert LaCAze, executive member of pharmaceuticals division as well as strategic business head at Bayer stated that Nubeqa approval had opened gates to a new therapy that aids in extending MFS besides allowing physicians more flexibility in treating men having nmCRPC.

As per Matthew Smith, MD, PhD, director at the Massachusetts General Hospital Cancer Centre in Boston for Genitourinary malignancies program, The approval of Nubeqa has opened the gates for a new option in prostate cancer treatment. He added that the objective of the treatment was to curb the spread of the cancer besides controlling therapy side effects as Patients usually do not exhibit any typical symptoms of MFS.

*Sourced from the Internet

VIMS&RC is one of the Best Cancer Hospital in Bangalore 

Tension Headache – Know More

One of the most common headache types in India and across the world amongst adults particularly is the tension headache. Mostly they are known to occur once or twice in a month, but could be chronic as well. The former kind of headaches are known as episode headaches.

Tension Headache

Causes

  • There are many reasons behind getting tension headaches including stress due to work, relationships and more

  • Women are known to be more prone to tension headaches as compared to men.

  • Daily stress can cause chronic tension headache while episodic will be due to periodic stress issues.

Symptoms

Usually tension headache starts in the second half of the day

  • Fatigue

  • Sleeping issues

  • Moderate headache or pressure on sides, top and front of the head.

  • Sensitivity to noise and light

  • Muscle pain

  • Focusing issues

Compared to migraine tension headaches are bearable and do not interfere with daily activities. They also not cause vision blur. There is no nausea or vomiting, stomach pain or light or noise sensitivity.

Treatment

As the saying goes ‘a stitch in time saves nine’, tension headaches are good to be treated when there are milder. To prevent them avoid triggers and take medications, usually over the counter ones. In case they do not work is when your doctor would prescribe you some muscle relaxants or strength medications.

Tension headaches aren’t life threatening or do not need prompt or emergency medical assistance. Having said that, if you experience a severe headache of abrupt nature, or a headache post a head injury or accompanies with mental confusion, fever, double vision, numbness or speaking difficulties, take emergency medical assistance right away.

Tension headaches can be prevented by exercising on a daily basis and relaxation and biofeedback as well as cognitive and other therapies in addition to lifestyle changes that include following a healthy life style like drinking a lot of water, eating regular balanced diet and limiting your intake of sugar, caffeine and alcohol.

*Sourced from the Internet

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Stomach Cancer – Causes, Symptoms, Diagnosis And Treatment

Stomach cancer is one of the most common cancers in India particularly in north eastern parts of India. Hospital based data from Mizoram shows around 30 percent of the admitted cancer patients suffering from gastric cancers.

Alike other cancers symptoms of stomach cancer are not apparent in the beginning and are similar to symptoms like common health conditions like flu and more. The symptoms for stomach cancer include –

Stomach Cancer

  1. Unexplained Weight loss

  2. Abdominal Pain

  3. Nausea and vomiting

  4. Discomfort in the area above the belly button

  5. Bloating post small meals

  6. Indigestion and heartburn

  7. Anemia

  8. Blood in stool

As you can see, the aforementioned symptoms aren’t really a reliable indication for cancer. A stomach virus or ulcer could also have these symptoms. The indicative symptoms only occur once the cancer is at advanced stage.

Risk Factors

Risk factors for stomach cancer include genetic history of cancer and smoking as well. Helicabacter Pulori (H pylori) bacterium infection is also one of the major causes of stomach cancer. Having said that, though many people who do have the germ inside them do not get cancer.

Treatment

Treatment is based on the diagnosis and could involve surgery, chemotherapy or radiation therapy. Usually, the treatment involves either curing the condition if it is in the early stages or controlling or relieving the symptoms. If the objective is cure then the treatment also concentrates on relieving the side effects. If the objective is to keep the cancer under control, the treatment involves relieving symptoms that affect the quality of life like eating problems, pain and bleeding. A second opinion is always advisable when it is about cancer.

Prevention

Though cancer is not preventable as such but what you can do is only manage the risk factors through a balanced diet rich in fibres and cirtrus fruits, exercise and physical activity.

*Sourced from the Internet

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All You Need To Know About Asthma

Asthma is one of the common conditions and as per statistics it is ranked in the top 20 conditions causing disability across the world. The alarming part is that one in every 10 asthma patients in the world is from India. Bronchial asthma is one of the most chronic forms of asthma and the symptoms vary from person to person.

Asthma can go from being just a minor respiratory issue to a condition that could affect your quality of life depending upon its severity. If you see your symptoms worsen with time, that’s the sign.

asthma

Asthma Symptoms

  • Breathing issues and shortness of breath

  • A whistling sound while breathing out

  • Pain in the chest or tightness

  • Attacks of wheezing and cough during a viral respiratory infection like cold or flu

Asthma Triggers

There are certain infections and allergies that can trigger and aggravate asthma. They include the following

Allergies – A lot of allergies tend to trigger asthma including dried pet saliva, airborne substances like molds, spores and pollens, waste particles to name a few.

Occupational – It usually occurs at the workplace due to triggers like dust, gases and chemical fumes

Exercising – It usually occurs during exercising or rigorous physical activity and worsens as the air gets cold and dry

GERD – Asthma is also caused in people with Gastroesophageal reflux disease (GERD)

Food Preservatives – Some preservatives and sulphites in foods as well as beverages can also trigger asthma

If proper treatment is provided then it works really well with asthma and prevent further aggravation of the same. Though prevention of asthma is not a possibility, you can definitely work towards avoiding asthma attacks through proper care of yourself. This includes

*Sourced from the Internet

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Biopsy – All You Need To Know About Biopsy

For a variety of cancers the only way to provide a definite diagnosis about a condition is to carry out biopsy. The procedure involves the removal of a sample of cells or a tissue from the body for a closer examination.

Biopsy - Types of Biopsy

Types of Biopsy

Needle Biopsy – This type of biopsy is used mostly for diagnosis of cancers that can be felt through the skin. These include enlarged lymph nodes as well as breast nodes

  • Fine needle aspiration A needle and a syringe is used to get a sample from either breast lump or thyroid.

  • Vacuum assisted biopsy – There’s a suction device is used to extract more amount of fluid at a time so that the needle does not have to be inserted many times.

  • Image guided biopsy - Image guided biopsy uses a combination of imaging procedures like computerized tomography (CT), X-ray, sonography or MRI.

  • Core needle biopsy – It uses a needle that is larger with a cutting tip to draw the sample column of tissue.

Endoscopic Biopsy- An endoscope is used for taking tissues from the stomach during endoscopy. An endoscope is a tube with a camera at its end.

Incisional Biopsy – It involves taking a small part of skin

Excisional Biopsy – It involves taking a big part of the tissue/ tumor and requires a

Skin Biopsy – The procedure is carried out in order to check for lesions, rashes, growth, moles and lesions. The doctor takes samples of your skin surface with the help of a razor.

Punch Biopsy – A small instrument is used to punch a hole in the skin in order to get a sample.

Bone Marrow Biopsy – This biopsy involves taking samples of the bone marrow to check for cancerous or non-cancerous cells causing blood problems. A sample of the bone marrow is taken for diagnosis around cancers like lymphoma, leukemia and more.

Yes, biopsy does sound freaky but with the advanced procedures in place, its mostly a low risk as well as pain free procedure. So, if you are to undergo a biopsy procedure soon, do not panic. Stay calm, there’s nothing to worry about it.

*Sourced from the Internet

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Tree Man Condition – A Rare Genetic Disorder That Urged A Man To Request Doctors To Amputate Hands.

Also Known as Tree man syndrome, epidermodysplasia verruciformis (EV) is a rare genetic disorder putting the patient to high risk of skin cancer. It is known as Tree Man because the when the condition occurs, the virus spreads around the body to create tree like growth. Our body has over 100 strains of HPV but if the human body has a genetic mutation that affects the ability to handle HPV negatively, it results in Tree man Disease.

epidermodysplasia verruciformis

Recently, the news about a man with epidermodysplasia verruciformis seeking help from doctors to amputate his affected hands went viral. He was undergoing extreme and unbearable pain and wasn’t able to afford better treatment. He was treated earlier but the condition returned bigger and faster. Now, inorder to seek treatment outside Bangladesh required enormous funds which he didn’t have. This is when the Prime minister of Bangladesh offered him free Treatment. Most of us till the video went viral, weren’t even aware of a condition like this one. The sad news is that it is a condition one needs to live with as it is for life. Even if treatment is provided by removal of the existing lesions, it returns again. Furthermore 50% of the people suffering from this condition can get skin cancer at the age of around 40-50 years.

As on day, there is not cure for the condition so immediate treatment becomes very important. The condition does involve a surgery called curettage. The term is derived from the device called curette used in the surgery. The device is spoon shaped and the lesion is scrapped off with the help of this device in-order to preserve the skin underneath. The EV warts are treated using traditional methods of treating warts like ointments, chemical treatments and cryotherapy.

The symptoms are generally visible around early years of 5 to 11. The symptoms include beginning on flat lesions on skin areas that are exposed to sunlight and even scab like lesions, papules, plaques or bumpy lesions. The lesions can occur across the body including hands, legs, armpits and more. The growth could be less limited to a small cluster of warts or aggravate to over 100 warts across the body too. The diagnosis is tricky as the doctor requires the medical history of the patient in order to understand the symptoms. The diagnosis involves physical examination of skin and biopsy procedure if the doctor suspects.

Living with Epidermodysplasia Verruciformis could affect the quality of life of a person suffering from the condition if it aggravates as it could get painful too. As a part of care with EV, limiting exposure to sun is very important as skin cancer risk is high. So, if you know someone in your relative or family with this disease, then it’s advisable that you visit your doctor for checkup.

*Sourced from the Internet

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Effects Of Cancer On Mental Health

Even today after so much advancement in the field of healthcare and medicine and so much rewarding research around cancer, it still remains a dreaded disease for people. Yes, innovation and research in the cancer field has brought about a lot of hope in terms of increasing longevity and improvement in quality of life, even today when we hear of been diagnosed with cancer, we do get goose bumps or a shocker. These days’ people have become quite vocal about disclosing the diagnosis to people and sharing their experiences particularly celebrities are quite vocal about it. Even though, different people experience differently depending upon their individual mental health.

Most of us feel that having cancer means a physical condition that is life threatening, causes fatigue, hair loss and nausea. But, beyond physical issues, comes the mental health issue which we are not able to see. Some might tell about it while some may not but the fact of the matter remains that hearing the news does not get easier for anyone. There comes some point in life where most of the cancer patients slip in depression. Here are the most common feelings that storm through the minds of cancer survivors –

cancer Hospital in Bangalore

DEPRESSION – As per the National Cancer Institute, depression is known to affect around 15 to 25 percent of the cancer population. The condition is a result of diagnosis itself primarily. Other reasons for depression include cancer side effects, anxiety around the future with cancer, change in image of self, to name a few. Depression is not the same as feeling sad, it comes with symptoms like fatigue, emptiness, mood swings, worthlessness to name a few.

vims bangalore

GRIEF – Grief is not limited to the cancer patient but to his family and relatives as well for the period through the cancer battle. There is this term called anticipatory grief, apparently a mix of emotions that come when we live with a personal loss experience that results into grieving. This same grief is experienced by cancer patients and their relatives. Although it is normal to experience grief in such times, but grieving alone isn’t advisable.

ANXIETY – Anxiety is one of the most common problems that cancer patients face around their future prognosis, future reports, treatment related issues to name a few. The cancer community has also coined a special work for anxiety around future scans, calling it scanxiety.

All these mental health issues do need to be looked into and consulting a mental health specialist or therapist surely does help. Well, it important to understand that if mental health is better, the healing is faster and even the quality of life.

Vydehi is one of the best cancer hospital in banglaore, recently vims started VOICE – Vydehi Oncology Institute and Center of Excellence

*Sourced from the Internet

Risk of Breast Cancer in Trans Women Post Hormone Therapy Escalates To Over 45 Times

A Study has found that trans-women undergoing the gender change procedures increase their risk of getting breast cancer by over 46% as compared to men. The study was carried out on over 2000 trans-women and it was found that after undergoing the sex change procedures 1 in 200 came under the risk scanner of breast cancer as compared to less than 8000 in men.

Cancer hospital in Bangalore

The studies that were carried out earlier have shown that hormone replacement therapy (HRT) does increase the risk of breast cancer particularly in women post menopause. Suggestively, it would increase the risk in trans-women undergoing hormone treatment.

vims bangalore

As study involving 2260 women, 15 cases of invasive breast cancer came to light of that of women of over 50 years of age post 18 years on an average of hormone therapy. Dr. Martin Den Heijer from Amsterdam University Medical Centre says that the issues and side effects of hormone therapy are knowns are discussed also with the people who undergo treatment.

Though the risk for naturally born women is one third less, the experts from Netherlands said that not only the patients but even the doctors needed to be aware of the fact that injections of female hormones do have an increased threat.

vydehi medical institutes in bangalore

In Britain there has been a drastic rise in the number of operations and it’s around 250 per year presently as compared to 54 around 2000. The researchers were unclear though if some of the cases were genetic or due do lifestyle because one of their trans gender woman study did carry the BRCA gene mutation that lead to breast cancer. Besides, it also showed that trans- gender men were at a considerably lower risk as compared to female population. The study that determined the same involved 1229 trans men of which four had invasive breast cancer have diagnosed at 47 years post 15 years of hormone treatment.

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*Sourced from the Internet.

Cancer Vaccine that can Cure 97% of Tumor from Mice Approved for Human Trial

Yes, you read that right. As per researchers of Stanford University, a vaccine they tested on mice has worked well in curing around 97% of the tumors in mice and is ready for human trial. According to SFGate. the human trial is scheduled to be conducted on 35 people suffering from lymphoma before the year ends.

The study was earlier tested on mice with cancers ranging from colon, breast and lymphoma. The results were welcoming, because this treatment cured around 87 mice out of the 90. The best part is that tumors in some mice had spread through other parts of the body too and even then they could be cured.

Cancer Vaccine That can Cure 97% of Tumor from Mice Approved for Human trial

As per the regional director of breast surgery at North-well Health Cancer Institute in Westchester, New York, even if the news was exciting enough, the results on animals might not be the same as that on humans. So, there is still a long way to go before the treatment works for particularly cancers other than lymphoma, viz. breast and colon.

Though it is called a vaccine, technically it ain’t. It is more of an immunotherapy. It is still given the name of a vaccine for a reason that is does contain a vaccine like injection. Also, as per the American society of clinical oncology, cancer vaccines can be used for referring treatment of cancer and preventing it from coming back. This vaccine involves the injection of the vaccine into the existing tumor. It does the role of reactivating the T cells. These T cells are responsible for infiltrating and attacking the cancer cells. But, as the tumor increases, the cancer tells suppress these T cells.
Immunotherapy is not something new though. It has been in practice for quite some time. A treatment called CAR t-cell therapy has been already approved some time back for leukemia as well as lymphoma. This therapy is about removing certain immune cells from the body and genetically engineer these cells so that they become capable of fighting cancer.

But, the advantage of this therapy over CAR T-cell therapy is that nothing from the body is to be removed or customized. Here it’s just targeted therapy where the doctors will be concentrating and attacking specific targets.

Though this study is one step forward in the direction to treat cancer but still it’s a long way to go.

Vydehi Institute of Oncology & Research Centre is one of the first centers in India to commission IGRT (Image guided radiation therapy) with respiratory gating apart from having other radiation equipment like High Dose Rate Brachytherapy (HDR).

*Source from the Internet

One Blood Test to Diagnose 8 Different Cancers

A recent study has revealed the ability of one blood test to detect as many as eight types of cancers with perfection. The study was carried out by a team of researchers at the John Hopkins University of Medicine, Baltimore and even published in the Science Journal. The study was carried out over 1000 people with the disease and showed high specificity and sensitivity as well.

Today, even with many innovations and advances in science, Cancer is still not having a cure. While research is on, the estimated death toll by 2030 across the world due to cancer can go up to a staggering 8-13 million range.

One Blood Test to Diagnose 8 Different Cancers

Because, cure is still to be found, the effectiveness of the treatment is limited to restricting the spread of the cancer cells and increasing life span. An early diagnosis is always beneficial in cancer but sadly, by the time you become aware of the cancer in your body, it is too late and its spread to other parts. The reason is lack of advanced tools for diagnosis. But, here’s some good news from the research team at John Hopkins University could crack the code to simple way to detect cancer that too in the early stages.

The idea is to detect small fragments of mutated DNA as well as proteins that the cancerous tumors release in the blood stream, when they are formed, thus helping to detect cancer through a blood test. The researchers revealed that the new blood test has the ability to identify 16 gene mutations as well as 8 proteins linked to eight different cancer types.

The cancers include colorectal cancer, lung cancer, breast cancer and five others that even today do not have routine screening tests for people with average risk namely pancreatic cancer, liver cancer, esophageal cancer, stomach cancer and ovarian cancer.

As per the Cristian Tomasetti, associate professor of oncology and biostatistics of John Hopkins University, the uniqueness of this classification method in observing different levels of Proteins together with DNA mutations in order to reach to a final decision.

The Cancer SEEK test was performed on 1005 individuals in total and successfully identified 70% of the cancers with high sensitivity ranging from 33% in breast cancer cases and upto 98% in ovarian cancer cases. In the five cancers which do not have routine screenings, the test performed even better showing a sensitivity of 69% to 98%.

As far as specificity is concerned the range was 99% and out of the 812 people tested, it only showed seven false results. What’s more the test was even able to detect the location of the tumor in over 80% of the patients.

As per the researchers, it will take further study to determine its efficacy as a routine screening test for cancer detection but the results are encouraging and definitely paves the way towards improving quality of life of cancer patients through early detection.

VIMS is one of the best cancer hospital in India, with 300 beds exclusively for cancer patients.Oncology department in the hospital has got qualified and well experienced doctors