We all know pretty well that too much of fat in body can lead to serious health and cardiovascular problems. But, little do we know that even too little fat can lead to cariovascular issues, as per a recent study. This is a rare condition and is known as Congenital lipodystrophy. It is the polar opposite of high fat condition known as obesity, which we are all aware off and has the ability to damage the heart in the same way as high fat levels.
Fat helps regulate use and storage of fat and is a major leptin producer, considered to be of significant importance in cardiovascular health. If someone has the congenital lipodystrophy condition, then the leptin and fat content is very low. Further, when they consume lipids or fat, there is no way to go and they get stored or piled up rather in the heart, muscle or liver. This is quite unnatural and not good for body organs, thus increasing the risk of diabetes and cardiovascular diseases. There seems to be a visible solution in the pipeline for this condition though and it is called Leptin replacement therapy. Though its effects are largely unknown, doctors are of the opinion that is is a good therapy and works well. It actually restores the endothelial function that get’s impaired when a patient suffers from this condition besides restoring the healthy glucose levels as well.
Now endothelial cells are responsible for production of eNOS,, a dilator, powerful enough to enable the blood vessels to relax. In the condition of lipdystrophy, the NOX1 enzyme expression increases thus producing reactive oxygen species of high damaging levels. The scientists are therefore studying the relationship of endothelial cells and leptin and explore further interactions wherein the want to watch on results of giving too much leptin, could lead to negative results though early on they seem to be positive.
Alternative treatments suggest liposuction of fat deposit removal in addition to exercise and balance diet intake.
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